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ProteomicsAZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
Phosphorylation of RNA polymerase II by cyclin-dependent kinase 9 (CDK9) is crucial for transcriptional regulation, and acute inhibition of CDK9 results in the rapid downregulation of genes with short-lived transcripts and labile proteins. Multiple non-selective CDK9 inhibitors have progressed clini...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013796 | Pride
A selective cdk9 inhibitor Azd4573 Targets mcl-1 
ProteomicsEpendymoma instructs cranial haematopoiesis and immunotolerance
ZFTA-RELA ependymoma presents a significant clinical challenge due to the lack of effective treatments, driving the need to explore novel immunotherapeutic strategies. Recent studies have identified the skull bone marrow as a source of meningeal immune cells critical for central nervous system (CNS)...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD058239 | Pride
Immune surveillance Skull bone marrow Csf Hematopoiesis Regulatory t cell Childhood brain tumour Ependymoma 
ProteomicsThe Histone Acetyltransferase MOZ is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML), and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However, the composition and consequences of NUP98 FO-associated condensates are incompletely understood. H...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058286 | Pride
Histone acetyltransferase Gene fusion Leukemia Nup98 
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