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TranscriptomicsRNA-Seq data of terminal differentiated cells in Dictyostelium discoideum
The intent of the experiment was to gather transcriptomic data from terminally differentiated cell types --spore, stalk, and cup cells-- in a simple multicellular model system, Dictyostelium discoideum, in order to characterize the cell-type specific gene expression patterns. Specifically, we dissoc...
ORGANISM(S): Dictyostelium discoideum 
2019-01-31 | E-MTAB-7215 | biostudies-arrayexpress
TranscriptomicsThe small RNA repertoire of Dictyostelium discoideum
Small RNAs play crucial roles in regulation of gene expression in many eukaryotes. Here, we report the cloning and characterization of 18-26 nt RNAs in the social amoeba Dictyostelium discoideum. This survey uncovered developmentally regulated microRNA candidates whose biogenesis, at least in one ca...
ORGANISM(S): Dictyostelium discoideum 
2007-10-16 | E-GEOD-8755 | biostudies-arrayexpress
TranscriptomicsAllorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoebae Dictyostelium discoideum
The social amoeba Dictyostelium discoideum integrates into a multicellular organism when individual starving cells aggregate and form a mound. The cells then integrate into defined tissues and develop into a fruiting body that consists of a stalk and spores. Aggregation is initially orchestrated by ...
ORGANISM(S): Dictyostelium discoideum 
2016-04-13 | E-GEOD-68063 | biostudies-arrayexpress
TranscriptomicsLeaps and lulls in the developmental transcriptome of Dictyostelium discoideum
Development of the soil amoeba Dictyostelium discoideum is triggered by starvation. When placed on a solid substrate, the starving solitary amoebae cease growth, communicate via extracellular cAMP, aggregate by tens of thousands and develop into fully integrated multicellular organisms. Early phases...
ORGANISM(S): Dictyostelium discoideum 
2015-04-21 | E-GEOD-61914 | biostudies-arrayexpress
TranscriptomicsTranscriptome conservation of the D. discoideum and D. purpureum developmental programs revealed through RNA-sequencing
Cross species comparison of genomes and transcriptomes is a powerful tool for understanding underlying biological processes, accurate functional classification of genes, and discovery of novel elements. The shift to next-generation sequencing platforms has tremendously accelerated the analysis of ge...
ORGANISM(S): Dictyostelium purpureum 
2010-03-12 | E-GEOD-17637 | biostudies-arrayexpress
TranscriptomicsBacterial discrimination by Dictyostelid amoebae reveals the complexity of ancient interspecies interactions
Transcriptional profiling of D. discoideum revealed sets of genes whose expression is enriched in amoebae interacting with different species of bacteria, including sets that appear specific to amoebae interacting with Gram(+), or with Gram(-) bacteria. In a genetic screen utilizing the growth of mut...
ORGANISM(S): Dictyostelium discoideum 
2013-05-20 | E-GEOD-46386 | biostudies-arrayexpress
GenomicsDictyostelium discoideum
D. discoideum NC4 transcriptome data
PRJNA80129 | ENA
TranscriptomicsTranscription profiling of Dictyostelium discoideum wild type and dupA null after infection with Legionella pneumophila
The social amoeba Dictyostelium discoideum is vulnerable to infection by the pathogen that causes Legionnaire's Disease, Legionella pneumophila. Dictystelium cells lacking the dual-specificity phospahatase DupA are at least partially resistant to infection, and strikingly the expression profile of u...
ORGANISM(S): Dictyostelium discoideum 
2009-09-24 | E-TABM-509 | biostudies-arrayexpress
TranscriptomicsMicroRNAs in Amoebozoa: Deep sequencing of the small RNA population in the social amoeba Dictyostelium discoideum reveals developmentally regulated microRNAs
We found 16 miRNAs in D. discoideum. Several were differentially expressed during growth and multicellular development. HTS of small RNAs was analyzed to identify miRNAs. Some of the miRNAs were then further verified using different experimental approaches.
ORGANISM(S): Dictyostelium discoideum 
2012-08-31 | E-GEOD-38361 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Dictyostelium discoideum AX2 upon infection with wt L. pneumophila JR32 vs. the L. pneumophila delta DotA mutant 24h p.i.
Differential gene expression of Dictyostelium discoideum after infection with Legionella pneumophila was investigated using DNA microarrays. A detailed analysis of the 24 h time point post infection was performed in comparison to three controls, uninfected cells and co-incubation with Legionella hac...
ORGANISM(S): Dictyostelium discoideum 
2013-09-07 | E-GEOD-50536 | biostudies-arrayexpress
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