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MetabolomicsCharacterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling
This study centered on detecting potentially anti-inflammatory active constituents in ethanolic extracts of Chinese Lonicera species by taking an UHPLC-HRMS-based metabolite profiling approach. Extracts from eight different Lonicera species were subjected to both UHPLC-HRMS analysis and to pharmacol...
2022-11-17 | MTBLS3112 | MetaboLights
UnknownLingzhi and San-Miao-San with hyaluronic acid gel mitigate cartilage degeneration in anterior cruciate ligament transection induced osteoarthritis.
Not available
S-EPMC7773973 | biostudies-literature
Unknown[Effects of Sidaxue, a Miao ethnomedicine recipe, on apoptosis and pyrolysis of human fibroblast-like synovial cells in rheumatoid arthritis].
Not available
S-EPMC8586859 | biostudies-literature
ProteomicsGCN5 associated complex in human malaria Plasmodium falciparum
The histone acetyltransferase (HAT) GCN5-associated SAGA complex is evolutionarily conserved from yeast to human and functions as a general transcription co-activator in global gene regulation. To study GCN5 associated complex in human malaria parasite Plasmodium falciparum, PfGCN5 was tagged with P...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-08-06 | PXD023389 | Pride
Gcn5 Malaria Plasmodium falciparum 
Proteomicshistone post-translational modification during Plasmodium falciparum gametocyte development
Histone post-translational modifications (PTMs) play an essential role in epigenetic gene regulation. The Plasmodium falciparum genome encodes canonical and variant histones and a collection of conserved enzymes for histone PTMs and chromatin remodeling. Herein, we characterized the P. falciparum hi...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-09-14 | PXD031817 | Pride
Malaria Gametocyte Histone Plasmodium falciparum 
MetabolomicsSystem Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights
ProteomicsLC-MS/MS analysis of immunoprecipitation samples of a Tetrahymena TFIIB-like protein Emit3 and the zinc-ribbon mutated Emit3
Transposable elements (TEs) are threats to genome stability and thus small RNA-mediated heterochromatinization suppresses the transcription of TEs. Paradoxically, transcription of non-coding RNA (ncRNA) from TEs is needed for the production of TE-targeting small RNAs and/or recruiting the silencing ...
ORGANISM(S): Tetrahymena thermophila 
2025-05-13 | PXD057568 | Pride
Tetrahymena thermophila Immunoprecipitation Meiosis Ncrna transcription Lc-ms/ms 
Unknownm6A RNA modification controls autophagy through upregulating ULK1 protein abundance.
Not available
S-EPMC6123428 | biostudies-literature
ProteomicsAcetyl-proteome profiling of Staphylococcus aureus revealed lysine acetylation in bacterial antibiotic resistance
Protein post-translational modifications (PTMs) play crucial roles in various biological processes across prokaryotes and eukaryotes. Lysine acetylation (Kac), which is observed in different bacteria species and is known to be a dynamic and reversible PTM involved in numerous physiological functions...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD043277 | Pride
Post-translational modification  staphylococcus aureus  antibiotic resistance  lysine acetylation  ribosome 
ProteomicsPsAF5 functions as an essential adapter for PsPHB2-mediated mitophagy under ROS stress in Phytophthora sojae
Host-derived reactive oxygen species (ROS) is an important defense means to protect against pathogens. Although mitochondria are the main intracellular targets of ROS, how pathogens regulate mitochondrial physiology in response to oxidative stress remains elusive. Prohibitin 2 (PHB2) is an inner mit...
ORGANISM(S): Phytophthora sojae 
2024-05-21 | PXD044242 | Pride
Lc-msms Oomycete Mitochondria Phytophthora sojae 
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