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ProteomicsQuantitative proteomics of DAAO-TGTie2 aorta
We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amino acid oxidase (DAAO) under control of the endothelial Tie2 promoter. In DAAO-TGTie2 mice, DAAO generates the reactive oxygen species hydroge...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD060737 | Pride
Daao-tgtie2 Aorta 
ProteomicsAorta proteomic analysis thoracic-abdominal
Aortic aneurysms is increasing as the human population ages. Pathological oxidative stress is implicated in development of aortic aneurysms. We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amin...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD060700 | Pride
Oxidative stress Vascular biology Chemogenetics Aneurysm 
TranscriptomicsSensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress
In our chemogenetic neurovacular mouse model, DRGs transcriptomic analysis was performed by RNA-seq; Oxidative stress is associated with cardiovascular and neurodegenerative disease. We created transgenic chemogenetic mouse lines expressing yeast D-amino oxidase (DAAO) in endothelial cells and neuro...
ORGANISM(S): Mus musculus 
2023-05-01 | GSE229143 | GEO
UnknownDifferential aortic aneurysm formation provoked by chemogenetic oxidative stress.
Not available
S-EPMC12043099 | biostudies-literature
GenomicsSensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress
Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress
PRJNA953031 | ENA
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