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RNA-seq of mouse lung tissue from amiodarone and/or dabigatran treated animals
Dabigatran protection against lipopolysaccharide induced endotoxemia is not mediated through its anticoagulant function
Endotoxemia is a key feature of sepsis pathogenesis and has also been found to mediate the pathophysiology of multiple chronic inflammatory conditions. In this work, we expand upon a model of endotoxemia due to lipopolysaccharide (LPS) using zebrafish and demonstrate that this model displays activat...
ORGANISM(S): Danio rerio 
2025-10-03 | GSE245299 | GEO
Purpose: Determine the impact of thrombin inhibition with dabigatran etexilate on high fat diet-induced gene expression in livers of mice fed a high fat diet
ORGANISM(S): Mus musculus 
2017-07-12 | GSE50763 | GEO
Interstitial lung disease (ILD) is a group of respiratory disorders characterized by chronic inflammation and fibrosis of the pulmonary interstitial tissues. Although the etiology of ILD remains unclear, some drug treatments are one of the primary causes of ILD. In the present study, we analyzed FDA...
ORGANISM(S): Mus musculus 
2020-12-03 | GSE162229 | GEO
This dataset contains label-free quantitative (LFQ) LC-MS/MS proteomics data generated from human umbilical vein endothelial cells (HUVECs) treated with therapeutically relevant concentrations of the direct oral anticoagulants (DOACs) apixaban, rivaroxaban, edoxaban, and dabigatran, together with un...
ORGANISM(S): Homo sapiens (Human) 
2026-10-22 | PXD082155 | Pride
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