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TranscriptomicsIdentification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)
Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an or...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-16805 | biostudies-arrayexpress
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
UnknownIdentification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.
Not available
S-EPMC3502598 | biostudies-literature
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
TranscriptomicsNAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
The aim of this study is to determine if, using antioxidant drugs, it is possible to interfere with the proliferative capabilities of the human glioblastoma (GBM) tumor-initiating cells (TICs). To establish which cellular processes are activated in GBM TICs by the antioxidants NAC, Tiron and Trolox,...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44099 | biostudies-arrayexpress
UnknownOpportunity Screening for Early Detection of Gestational Diabetes: Results from the MERGD Study.
Not available
S-EPMC12565406 | biostudies-literature
TranscriptomicsSyntenin-1 is expressed in uveal melanoma and correlates with metastatic progression
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, being at that time almost always fatal. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-27831 | biostudies-arrayexpress
UnknownCarriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19.
Not available
S-EPMC9227269 | biostudies-literature
UnknownAssociation of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.
Not available
S-EPMC7987337 | biostudies-literature
UnknownMutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Not available
S-EPMC5819591 | biostudies-literature
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