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ProteomicsProteomic profiling of IBD circulating exosomes
Differential proteome profiling of IBD serum exosomes to find corresponding regulatory protein cargoes of serum exosomes in IBD progress. Exosomal proteins were extracted using SDT buffer lysis (4% SDS, 100mM Tris HCl, 1mM DTT, pH7.6), and the protein concentration was determined using the BCA prote...
ORGANISM(S): Homo Sapiens 
2023-07-07 | PXD043594 |
ProteomicsImproved biocompatibility of single-walled-carbon-nanohorns over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages (proteomics identification of total cellular proteins based on identical intracellular nanocarbons)
Single-walled-carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, t...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-25 | PXD009628 | Pride
Proteomics Gpnmb Nanotubes Single-walled-carbon-nanohorns Pyroptosis Nanosafety Apoptosis 
Proteomicsproteomics identification of total cellular proteins after five types of nanocarbon incubations with macrophages
Single-walled-carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, t...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-25 | PXD009635 | Pride
Proteomics Nanotubes Single-walled-carbon-nanohorns Nano-protein interaction Lc-ms/ms 
ProteomicsProteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor ant...
ORGANISM(S): Mus Musculus 
2024-07-05 | PXD053688 |
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
2025-10-14 | PXD069462 |
ProteomicsPhotocatalytic proximity labeling technology for nanoparticle protein corona
We designed a photocatalytic proximity labeling technology for in situ labeling of corona proteins. When nanoparticles were exposed in plasma, they were immediately irradiated to induce the photocatalytic reaction, in which the inner Ce6 activated BP in the outer layer. BP was then released from nan...
ORGANISM(S): Mus Musculus 
2022-06-23 | PXD034930 |
MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
ProteomicsAnti-Toxoplasma gondii effect of vorinostat in vitro and in vivo
Toxoplasma gondii is an important pathogenic protozoon that infects up to one-third of the world's population. In immunocompetent individuals, the infection generally is asymptomatic. However, in immunocompromised patients, the infection can lead to severe and fatal complications. This is due to the...
ORGANISM(S): Toxoplasma Gondii Rh-88 
2024-07-17 | PXD053997 |
ProteomicsScreening for the transcriptional factors interacted with Id1 in RAW264.7 cells
Proteins in RAW264.7 cells were extracted by CO-IP lysis buffer, Id1 antibody and agarose gel beads were added into the lysis buffer and rotated in 4°C overnight. The agarose gel beads were washed for 5 times by centrifugation, and denatured in 2 ✖️loading buffer. The denatured protein samples were ...
ORGANISM(S): Mus Musculus 
2023-10-17 | PXD046173 |
Proteomics20210901_WXY_TMT_2plex_3Rep_Huvec_proteins
Cells were harvested with intra-cellular proteins extracted and digested with trypsin. Peptides were then labeled with TMT using a TMT10plex mass tag labeling kit (Thermo Fisher Scientific) per the manufacturer’s instructions. TMT-labeled peptides were then separated by high pH reverse-phase high pe...
ORGANISM(S): Homo Sapiens 
2023-11-01 | PXD046601 |
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