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UnknownA Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia.
Not available
S-EPMC6032672 | biostudies-literature
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum+feces)

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. dista...

2023-03-17 | MTBLS6728 | MetaboLights
ProteomicsPKA plays a conserved role in regulating gene expression and metabolic adaptation
PKA regulates metabolism adaptation by phosphorylating Rpd3/HDAC1
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-12 | PXD058634 | Pride
Pka hdac1 rpd3 
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis feces)

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6742 | MetaboLights
ProteomicsQuantitative Proteomics Revealed the Changes of Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblasts Proliferation
Insufficient osteogenesis is greatly essential to osteoporosis. Bugu Shengsui Decoction, a compound formula for osteoporosis, has significant clinical effects in the treatment of osteoporosis. Yet the detailed mechanisms are unclear. In this study, we first evaluated the pharmacological effects of B...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD030275 | Pride
Osteoporosis Osteoblasts Bugu shengsui decoction Proliferation Quantitative proteomics Pi3k-akt Pharmacodynamic network 
MetabolomicsOrganic Acids Modulate Systemic Metabolic Perturbation Caused by Salmonella Pullorum Challenge in Early-Stage Broilers
The objectives of this study were to determine the protective effects of organic acids (OA) in broilers exposed to Salmonella Pullorum challenge at early stage and to explore the potential benefits of OA by metabolomics analysis. The treatment groups included non-challenged, S. Pullorum-challenged, ...
2021-05-17 | MTBLS1274 | MetaboLights
GenomicsGenome wide binding of Insensitive in w[1118] embryos
ChIP-seq for Drosophila Insensitive, together with IgG control. Chromatin extracted from 2.5-6h w[1118] embryos and 6.5-12h w[1118] embryos. Samples from two time points were analyzed: 2.5-6h embryos and 6.5-12h embryos. In each time point there is one Insv ChIP sample and one IgG control sample.
ORGANISM(S): Drosophila melanogaster 
2013-04-04 | E-GEOD-44176 | biostudies-arrayexpress
TranscriptomicsExpression in Drosophila Insensitive mutant
Affymetrix arrays measuring gene expression in 3 Drosophila Insensitive mutant embryos and 3 Drosophila wt mutant embryos 6 samples, 3 replicates of Insensitive mutants and 3 replicates of wt
ORGANISM(S): Drosophila melanogaster 
2013-04-04 | E-GEOD-44177 | biostudies-arrayexpress
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum)

Hepatic fibrosis decreased feces bile acid level. Hepatic fibrosis increased serum bile acid. This result showed that hepatic fibrosis inhibited the excretion of bile acid in clinical patients. This result provided phenotype for hepatic fibrosis patients. Bile acid was important indexes for liver...

2023-03-17 | MTBLS6732 | MetaboLights
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