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ProteomicsRewiring oncogenic transcriptional complexes with domain-alteration chimeras (DALTACs) in prostate cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084250 | Pride
Ar Prostate cancer P300 Daltac 
ProteomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084305 | Pride
Ar Prostate cancer P300/cbp Daltac 
ProteomicsRewiring oncogenic transcriptional complexes with Domain-ALTerAtion Chimeras (DALTACs) in prostate cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084247 | Pride
Daltac ar-p300/cbp prostate cancer 
GenomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [ChIP-Seq]
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC), where AR maintains oncogenic enhancer programs through dynamic, domain-specific interactions with the lysine acetyltransferase p300 and associated cofactors. Here, we describe a...
ORGANISM(S): Homo sapiens 
2026-06-18 | GSE310949 | GEO
TranscriptomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [RNA-seq]
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC), where AR maintains oncogenic enhancer programs through dynamic, domain-specific interactions with the lysine acetyltransferase p300 and associated cofactors. Here, we describe a...
ORGANISM(S): Homo sapiens 
2026-06-18 | GSE310948 | GEO
GenomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [RNA-seq]
Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [RNA-seq]
PRJNA1367581 | ENA
GenomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [ChIP-Seq]
Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer [ChIP-Seq]
PRJNA1367590 | ENA
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