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MetabolomicsTranscriptomic and Metabolomic Joint Analysis to Explore the Molecular Mechanisms of Different Resistant Poplar Varieties in Response to the Feeding Damage of Anoplophora glabripennis

In China, Asian longhorned beetle (ALB) infestations severely threaten poplar resources, the primary species used for shelterbelt afforestation. Two fast-growing poplar hybrids, Populus alba × (P. alba × P. glandulosa) ...

2026-03-11 | MTBLS14028 | MetaboLights
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
GenomicsColibactin DNA damage signature indicates mutational impact in colorectal cancer
Colibactin DNA damage signature indicates mutational impact in colorectal cancer
PRJNA607699 | ENA
TranscriptomicsCPD-seq mapping of UV damage formation and repair in yeast
UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. We have used a novel high-throughput sequencing method to precisely map UV-induced cyclobutane pyrimidine dimers (CPD...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-19 | E-GEOD-79977 | biostudies-arrayexpress
TranscriptomicsAltered levels of MOF and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR).
Full title: Altered levels of MOF (member of MYST family histone acetyl transferase) and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR). The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that altered le...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20193 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae mRNAs following oxidative stress and DNA damage
We subjected yeast to two stresses, oxidative stress, which under current settings induces a fast and transient response in mRNA abundance, and DNA damage, which triggers a slow enduring response. Using microarrays, we performed a transcriptional arrest experiment to measure genome-wide mRNA decay p...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-26 | E-GEOD-12221 | biostudies-arrayexpress
TranscriptomicsImpaired DNA damage metabolism promotes autoimmunity in TREX1 deficiencyÂ
Constitutive low level DNA damage is linked to innate immune activation. Hierarchical clustering of over 9000 transcripts revealed remarkably similar profiles in a patient with lupus erythematosus and a patient with AGS with up-regulation of genes involved in DNA damage signaling, p53-inducible gene...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-59233 | biostudies-arrayexpress
TranscriptomicsBmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis
This SuperSeries is composed of the following subset Series: GSE38622: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [telogen]. GSE38623: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epider...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-38625 | biostudies-arrayexpress
GenomicsIntegrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage
The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptom...
ORGANISM(S): Homo sapiens 
2015-04-18 | E-GEOD-55727 | biostudies-arrayexpress
TranscriptomicsTranslational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Ubiquitous expression of ALS-causing mutations in superoxide dismutase 1 (SOD1) provoke non-cell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes are now identified. Initial mutant...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-74724 | biostudies-arrayexpress
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