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ProteomicsA cytoplasmic tail motif directs HLA-E to clathrin-mediated endocytosis and valosin-containing-protein-mediated recycling
Recent discoveries highlight the effectiveness of major histocompatibility complex (MHC)-E-restricted CD8+ T cell responses in controlling certain infections, particularly in a rhesus cytomegalovirus (RhCMV68-1)-vectored simian immunodeficiency virus (SIV) vaccine. In this context, these responses a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD060886 | Pride
Proximity labelling Hla-e 
ProteomicsOncogenic Mutations of KRAS Modulate Its Turnover by the CUL3/LZTR1 E3 ligase Complex
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute up to 30% of human solid tumours including lung adenocarcinoma, pancreatic and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterati...
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD029725 | Pride
G13d Kras G12d 
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