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ProteomicsMutation-specific and common phosphotyrosine signatures of KRAS G12D and G13D alleles
KRAS is one of the most frequently mutated genes across all cancer subtypes. Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D). Although the biochemical differences between these two predomina...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD009843 | Pride
Sw48 Phosphoproteome G13d mutation G12d mutation Kras Signaling 
UnknownKRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Not available
S-EPMC6825300 | biostudies-literature
UnknownStructural dataset for the fast-exchanging KRAS G13D.
Not available
S-EPMC4773362 | biostudies-literature
UnknownDiscernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors.
Not available
S-EPMC7643456 | biostudies-literature
UnknownClinical significance of the KRAS G13D mutation in anastomotic recurrence of colorectal cancer.
Not available
S-EPMC10126653 | biostudies-literature
ProteomicsOncogenic Mutations of KRAS Modulate Its Turnover by the CUL3/LZTR1 E3 ligase Complex
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute up to 30% of human solid tumours including lung adenocarcinoma, pancreatic and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterati...
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD029725 | Pride
G13d Kras G12d 
UnknownIsoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Not available
S-EPMC6709685 | biostudies-literature
UnknownStructure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.
Not available
S-EPMC10788945 | biostudies-literature
UnknownNovel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Not available
S-EPMC11344056 | biostudies-literature
UnknownDynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab.
Not available
S-EPMC7222508 | biostudies-literature
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