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Isopeptide crosslinked proteins can be the product of transglutaminase or of exposure to organophosphorus toxicants (OP). Transglutaminase links glutamine to lysine with loss of ammonia. OP toxicants induce a link between glutamic acid and lysine with loss of water. Our goal was to establish crit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-07-12 | PXD026790 | Pride
Chronic low dose exposure to organophosphorus pesticides is associated with risk of neurodegenerative disease. The mechanism of neurotoxicity is unknown, though it is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD027203 | Pride
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