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GenomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
PRJNA1158741 | ENA
TranscriptomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
The embryonic transcription factor TBXT (brachyury) drives chordoma, a spinal neoplasm without effective drug therapies. TBXT’s regulatory network is poorly understood, and strategies to disrupt its activity for therapeutic purposes are lacking. We developed designed ankyrin repeat proteins that blo...
ORGANISM(S): Homo sapiens 
2025-07-31 | GSE276715 | GEO
ProteomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Aberrant expression of the embryonal transcription factor TBXT (also known as brachyury) drives chordoma, a rare spinal neoplasm with no effective drug therapies. The gene network regulated by TBXT is poorly understood, and strategies to disrupt its abnormal activity for therapeutic purposes are lac...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD055982 | Pride
Tbxt Chordoma Darpin Brachyury 
UnknownDARPins: an efficient targeting domain for lentiviral vectors.
Not available
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UnknownEpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer.
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S-EPMC7409335 | biostudies-literature
UnknownAmyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease.
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S-EPMC4175345 | biostudies-literature
UnknownG-Quadruplex Recognition by DARPIns through Epitope/Paratope Analogy.
Not available
S-EPMC9804223 | biostudies-literature
UnknownA rapid, site-selective and efficient route to the dual modification of DARPins.
Not available
S-EPMC4091302 | biostudies-literature
UnknownProtease-stable DARPins as promising oral therapeutics.
Not available
S-EPMC8861517 | biostudies-literature
UnknownHighly potent VEGF-A-antagonistic DARPins as anti-angiogenic agents for topical and intravitreal applications.
Not available
S-EPMC3526737 | biostudies-literature
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