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ProteomicsRegulation of mitochondrial function and protein homeostasis by hypoxia inducible factor 1 alpha in normoxia-mouse tissues
Hypoxia inducible factors (HIF), specifically, HIF1A, is continuously synthesized and degraded rapidly in normoxia. During hypoxia, HIF1A stabilization limits oxygen utilization and inhibits protein synthesis, but there are limited data on HIF1A function(s) in normoxia. Given the high energy needs o...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD041880 | Pride
Normoxia Hif1a Skeletal muscle Senescence 
ProteomicsRegulation of mitochondrial function and protein homeostasis by hypoxia inducible factor 1 alpha in normoxia-mouse cells
Hypoxia inducible factors (HIF), specifically, HIF1A, is continuously synthesized and degraded rapidly in normoxia. During hypoxia, HIF1A stabilization limits oxygen utilization and inhibits protein synthesis, but there are limited data on HIF1A function(s) in normoxia. Given the high energy needs o...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD045794 | Pride
Normoxia Hif1a Skeletal muscle Senescence 
ProteomicsHyperammonemia-dependent and independent skeletal muscle phosphoproteomic responses during exercise
Phosphorylation of skeletal muscle proteins mediates cellular signaling and adaptive responses to exercise. Bioinformatic and machine learning approaches identified preclinical models that recapitulate human exercise responses. Feature selection showed that muscles from treadmill running mice and ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-25 | PXD031372 | Pride
Mass spectrometry Hyperammonemia Skeletal muscle Phosphoproteomics 
ProteomicsMetabolic reprogramming during hyperammonemia targets mitochondrial function and post-mitotic senescence
Ammonia is a cytotoxic metabolite with pleotropic molecular and metabolic effects in non-hepatic tissue/cells targeting mitochondrial oxidative function that may contribute to post-mitotic senescence. Global molecular responses were determined by analysis of unbiased data followed by experimental va...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2021-11-22 | PXD027754 | Pride
Cytotoxic Ammonia Pca Hyperammonemia Portacaval anastomosis 
ProteomicsMitochondrial responses during hyperammonemia
Ammonia is a cytotoxic metabolite with pleotropic molecular and metabolic effects in non-hepatic tissue/cells targeting mitochondrial oxidative function that may contribute to post-mitotic senescence. Global molecular responses were determined by analysis of unbiased data followed by experimental va...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-17 | PXD026955 | Pride
Cytotoxic Ammonia Pca Hyperammonemia Portacaval anastomosis 
ProteomicsDysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction by inhibiting sirtuin mediated deacetylation
Perturbed metabolism of ammonia, an endogenous cytotoxic molecule, causes mitochondrial dysfunction with decreased nicotinamide adenine dinucleotide (NAD+) in skeletal muscle. Consistent with our previous report of enrichment of NAD metabolism and sirtuin pathways during hyperammonemia, NAD+-depende...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD033430 | Pride
Multiomic Mitochondria Redox ratio Hyperacetylation Sirtuin 
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