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ProteomicsDisruption of acetyl group balance in cardiomyocytes augments the mitochondrial acetylproteome without affecting respiratory function or heart susceptibility to pressure overload
Circumstantial evidence links the development of heart failure to perturbations in oxidative metabolism and corresponding shifts in post-translational modifications (PTMs) of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that acetyl-PTMs compromise mitochon...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-02 | PXD013935 | Pride
Lc-msms Mitochondria Mouse Heart Acetylation 
UnknownIncorporation of a Collagen-Binding Chondroitin Sulfate Molecule to a Collagen Type I and II Blend Hydrogel for Cartilage Tissue Engineering.
Not available
S-EPMC9191256 | biostudies-literature
UnknownTunable Blended Collagen I/II and Collagen I/III Hydrogels as Tissue Mimics.
Not available
S-EPMC11648590 | biostudies-literature
UnknownThe LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
Not available
S-EPMC9755964 | biostudies-literature
ProteomicsDisruption of acetyl-lysine turnover in muscle mitochondria promotes insulin resistance and redox stress without overt respiratory dysfunction
A double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl CoA buffering by carnitine acetyltransferase (CrAT), and lysine deacetylation by SIRT3, resulted in additive hyperacetylation of the mitochondrial proteome, which was augmented exponentially by chronic high fat feeding....
ORGANISM(S): Mus musculus (Mouse) 
2019-11-25 | PXD014586 | Pride
Protein acetylation Mitochondrial bioenergetics Insulin resistance 
ProteomicsProteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and enhanced cysteine metabolic pathways
Equine myofibrillar myopathy (MFM) causes exertional muscle pain and is characterized by myofibrillar disarray and ectopic protein aggregates of unknown origin. To investigate the pathophysiology of MFM, we compared the skeletal muscle proteome and 3 h post-exercise transcriptome of gluteal muscle i...
ORGANISM(S): Equus caballus (Horse) 
2019-11-12 | PXD009362 | Pride
Myopathy Horse Antioxidant Proteome 
ProteomicsAbsolute quantification of cohesin and its regulators in human cells
The organisation of mammalian genomes into loops and topologically associated domains (TADs) regulates gene expression. The formation and maintenance of loops and TADs depends on the protein complex cohesin, which also holds replicated sister chromatids together from S phase until mitosis. To unders...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012712 | Pride
Fluorescence-correlation spectroscopy Mass spectrometry Cell cycle Genome organization Cohesin Sister chromatid cohesion 
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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