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2 x 2 design, with 2 pooled total RNA samples (5 hemibrains per sample) per genotype (40,XY or 39,XY*O) hybridised to Mouse Gene 1.0 ST array to determine effect of genotype on brain gene expression
ORGANISM(S): Mus musculus 
Deficiency for the enzyme steroid sulfatase (STS) has been associated with postpartum behavioural phenotypes in mice and humans. Here, we compared whole brain gene expression in new mouse mothers acutely treated (two administrations, 48hrs apart) with the STS inhibitor 667-Coumate (10mg/kg p.o.) or ...
ORGANISM(S): Mus musculus 
The study demonstrates (i) spatial heterogeneity of endothelial responses to hypercholesterolemia in the aortic valve, (ii) that endothelial metabolism is not dysfunctional in early focal lipid insudation, and (iii) that protective endothelial pathways induced by hypercholesterolemia may initially i...
ORGANISM(S): Sus scrofa 
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the true nature of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissect...
ORGANISM(S): Mus musculus 
Peripheral regulatory T-cell (Treg) levels correlate with psychiatric outcomes in humans, and Treg-depletion induced by diptheria toxin administration in Foxp3DTR knock-in mice results in specific behaviour phenotypes. We examined the consequences of Treg depletion on whole brain gene expression i...
ORGANISM(S): Mus musculus 
Effect of X chromosome imprinting on gene expression in mouse embryonic brain.
ORGANISM(S): Mus musculus 
The Antibiotic Resistant Sepsis Pathogens Framework Initiative aims to develop a framework dataset of 5 sepsis pathogens (5 strains each) using an integrated application of genomic, transcriptomic, metabolomic and proteomic technologies. The pathogens included in this initiative are: Escherichia col...
ORGANISM(S): Streptoccous pyogenes 
2021-07-05 | PXD016913 | Pride
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