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ProteomicsEndoplasmic reticulum di-glycine modified proteome under p97/VCP inhibition
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S prote...
ORGANISM(S): Homo sapiens (Human) 
2018-03-12 | PXD008842 | Pride
Erad Digly Ubiquitin 
UnknownContrasting nutrient-disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid.
Not available
S-EPMC6175101 | biostudies-literature
UnknownGenomics of Environmental Salmonella: Engaging Students in the Microbiology and Bioinformatics of Foodborne Pathogens.
Not available
S-EPMC8100199 | biostudies-literature
ProteomicsLipid droplet-targeted APEX proteome
Lipid droplet (LD) function is regulated by a complement of integral and peripheral proteins that associate with the LD phospholipid monolayer. Defining the composition of the LD proteome has remained a challenge due to the presence of contaminating proteins in LD-enriched buoyant fractions. To over...
ORGANISM(S): Homo sapiens (Human) 
2017-12-22 | PXD007695 | Pride
Lipid droplet Apex Erad 
UnknownDiscovery of trypanosomatid parasites in globally distributed Drosophila species.
Not available
S-EPMC3639215 | biostudies-literature
ProteomicsHrd1 interaction proteomics - Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the degradation of misfolded and unoligomerized proteins in the early secretory pathway. ERAD substrates are detected and delivered to membrane-embedded dislocation complexes. Following transfer into the cytosol, substrates are rapidl...
ORGANISM(S): Homo sapiens (Human) 
2017-01-03 | PXD005633 | Pride
Erad Hrd1 Triacsin c 
UnknownThe bacterial communities of Drosophila suzukii collected from undamaged cherries.
Not available
S-EPMC4121540 | biostudies-literature
UnknownSingle particle cryogenic electron micrographs of respiratory complex I from Drosophila melanogaster thoracic muscle
Not available
EMPIAR-11272 | biostudies-other
UnknownEvaluation of nutrient content and caloric density in commercially available foods formulated for senior cats.
Not available
S-EPMC7517497 | biostudies-literature
ProteomicsTargeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses in bacterial pneumonia
The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. Here We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacterial pneumonia in humans and displays intrinsic innate...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050224 | Pride
Inflammation Pneumonia Dars2 
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