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ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo sapiens (Human) 
2015-12-02 | PXD002471 | Pride
Human Runx3 Histone h3 lysine 27 trimethylation Melanoma Ezh2 
ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079979 | MassIVE
ProteomicsA phase separation mechanism underlies development of cancer and aberrant organization of three-dimensional chromatin structure
Development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human hematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an aberrant chimera that invariably retains...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD023548 | Pride
Oncogenesis Homeodomain-containing transcription factor Intrinsically disordered regions (idrs) Bioid 
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