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UnknownPhase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Not available
S-EPMC4017711 | biostudies-literature
ProteomicsIdentifying global and mtCU independent MICU1 interactome utilizing BioID2 based proximity labeling and screening
MICU1 is a Ca2+-binding protein that regulates the mitochondrial Ca2+ uniporter channel (mtCU ) and mitochondrial Ca2+ (mCa2+) uptake. MICU1 knockout mice display perinatal lethality and disorganized mitochondrial architecture. These phenotypes are distinct from other mtCU loss-of-function models an...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD028462 | Pride
Bioid2 Mitochondria Calcium Proximity-labelling Mcu Micu1 
TranscriptomicsHost transcriptional response to influenza and other acute respiratory viral infections – a prospective cohort study
The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells and uncover the complex dynamics of host response to ARIs such as pandemic H1N1. To understand the molecular bases and network orchestration of host responses, we prospectively enrolled 1610 heal...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-68310 | biostudies-arrayexpress
MetabolomicsHabitual Coffee Intake Shapes the Gut Microbiome and Modifies Host Physiology and Cognition: double-blind, randomised, parallel design

Coffee influences multiple physiological processes, including gut function, stress, cognition, and the microbiome. However, the mechanisms underlying these effects remain poorly understood. In this study, we examined coffee’s impact on the microbiota–gut–brain axis—a bidirectional communication p...

2026-03-26 | MTBLS13401 | MetaboLights
UnknownAppetite Suppression and Altered Food Preferences Coincide with Changes in Appetite-Mediating Hormones During Energy Deficit at High Altitude, But Are Not Affected by Protein Intake.
Not available
S-EPMC6014054 | biostudies-literature
UnknownPhase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer.
Not available
S-EPMC3577951 | biostudies-literature
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
TranscriptomicsTranscription profiling of human lymphocytes from 1240 Mexican Americans for the discovery of expression QTLs
Transcriptional profiles were generated for lymphocyte samples from 1,240 randomly ascertained, mostly non-diseased Mexican American participants in the San Antonio Family Heart Study. Research findings related to the genetic regulation of expression levels are published in the following article: Go...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-TABM-305 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA expression in Dickkopf1-expressing versus control newborn mouse skin
miRNA expression was compared in skin from control newborn mice and littermate mice ectopically expressing the potent secreted WNT inhibitor Dickkopf 1 (DKK1) in the epidermis. DKK1 completely suppresses hair follicle development. Multiple miRNAs were identified that reproducibly produced signals ab...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-4723 | biostudies-arrayexpress
GenomicsThe Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3 Hormone [ChIP-seq]
Osteocytes are derived from osteoblast lineage cells that become progressively embedded in mineralized bone. Development of the osteocytogenic cell line IDG-SW3 has enabled a temporal and mechanistic investigation of this process. Through RNA-seq analyses, we show that while substantial changes in...
ORGANISM(S): Mus musculus 
2014-05-30 | E-GEOD-54782 | biostudies-arrayexpress
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