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ProteomicsIdentifying global and mtCU independent MICU1 interactome utilizing BioID2 based proximity labeling and screening
MICU1 is a Ca2+-binding protein that regulates the mitochondrial Ca2+ uniporter channel (mtCU ) and mitochondrial Ca2+ (mCa2+) uptake. MICU1 knockout mice display perinatal lethality and disorganized mitochondrial architecture. These phenotypes are distinct from other mtCU loss-of-function models an...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD028462 | Pride
Bioid2 Mitochondria Calcium Proximity-labelling Mcu Micu1 
TranscriptomicsAnalysis of the role of Micu1 in maintaining functional homeostasis in mouse liver
In this study, we analyzed global liver gene expression in MICU1 knock-down (KD) mice. To generate liver-specific MICU1 KD mice, MICU1loxp/loxp male mice were treated with an AAV8-Cre under the control of a hepatocyte specific promoter (TBG). AAV8-TBG-Null treated littermates were used as controls. ...
ORGANISM(S): Mus musculus 
2016-01-10 | E-GEOD-69801 | biostudies-arrayexpress
TranscriptomicsAnalysis of the role of Micu1 in maintaining functional homeostasis in mouse liver
In this study, we analyzed global liver gene expression in MICU1 knock-down (KD) mice. To generate liver-specific MICU1 KD mice, MICU1loxp/loxp male mice were treated with an AAV8-Cre under the control of a hepatocyte specific promoter (TBG). AAV8-TBG-Null treated littermates were used as controls. ...
ORGANISM(S): Mus musculus 
2016-01-10 | GSE69801 | GEO
UnknownMICU1 drives glycolysis and chemoresistance in ovarian cancer.
Not available
S-EPMC5477507 | biostudies-literature
UnknownMICU1 motifs define mitochondrial calcium uniporter binding and activity.
Not available
S-EPMC3919628 | biostudies-literature
UnknownMelatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway.
Not available
S-EPMC7834983 | biostudies-literature
UnknownMicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer.
Not available
S-EPMC7534609 | biostudies-literature
UnknownMICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions.
Not available
S-EPMC10175726 | biostudies-literature
UnknownA High-Throughput Screening Identifies MICU1 Targeting Compounds.
Not available
S-EPMC7034061 | biostudies-literature
UnknownMICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Not available
S-EPMC11363308 | biostudies-literature
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