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TranscriptomicsThe Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo
Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress
TranscriptomicsmRNA Expression Changes Induced by Myocardial MCU Inhibition
Mitochondrial calcium is an important second-messenger controlling fight-or-flight responses in the heart. The molecular identity of MCU (Mitochondrial Calcium Uniporter) was recently discovered allowing us to test this hypothesis in vivo by expressing a myocardial delimited dominant negative form ...
ORGANISM(S): Mus musculus 
2015-06-07 | E-GEOD-62049 | biostudies-arrayexpress
ProteomicsIdentifying global and mtCU independent MICU1 interactome utilizing BioID2 based proximity labeling and screening
MICU1 is a Ca2+-binding protein that regulates the mitochondrial Ca2+ uniporter channel (mtCU ) and mitochondrial Ca2+ (mCa2+) uptake. MICU1 knockout mice display perinatal lethality and disorganized mitochondrial architecture. These phenotypes are distinct from other mtCU loss-of-function models an...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD028462 | Pride
Bioid2 Mitochondria Calcium Proximity-labelling Mcu Micu1 
GenomicsRNA-seq of zebrafish adult MCU mutant hearts
RNA-seq of zebrafish adult MCU mutant hearts
PRJEB40865 | ENA
GenomicsParaburkholderia tropica strain:MCu-82
Paraburkholderia tropica MCu-82 genome sequencing
PRJNA547264 | ENA
ProteomicsUnbiased mapping of the MCU interactome
Mitochondria play a key role in Ca2+ homeostasis and thus the regulation of metabolism and cell death. The MCU is an ion channel that mediates the rapid and highly selective uptake of Ca2+ into the mitochondrial matrix. However, an in-depth characterization of the molecular links that couple MCU-dep...
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD040893 | Pride
Mcu Proteomics Mitochondria Calcium 
ProteomicsMCU interactome from mitochondria proteome
The interactome of MCU was determined by AP-MS in a minaturised approach. This dataset was the test dataset to demonstrate the robustness of the method.
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD029646 | Pride
Mitochondrial calcium uniporter Mitochondria Mcu 
TranscriptomicsmRNA Expression Changes Induced by Myocardial MCU Inhibition
Mitochondrial calcium is an important second-messenger controlling fight-or-flight responses in the heart. The molecular identity of MCU (Mitochondrial Calcium Uniporter) was recently discovered allowing us to test this hypothesis in vivo by expressiing a myocardial delimited dominant negative form ...
ORGANISM(S): Mus musculus 
2015-06-07 | GSE62049 | GEO
GenomicsNext Generation Sequencing of exosomal microRNA derived from MCU downregulated and control MDA-MB-231 cells.
Next Generation Sequencing of exosomal microRNA derived from MCU downregulated and control MDA-MB-231 cells.
PRJNA451104 | ENA
GenomicsAnalysis of the role of Mcu in the regenerating mouse liver after partial hepatectomy
Analysis of the role of Mcu in the regenerating mouse liver after partial hepatectomy
PRJNA573719 | ENA
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