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TranscriptomicsEmbryo exposure to heat shock and teratogen
Analysis of embryos exposed to either: [1] 40 uM 4-hydroperoxycyclophosphamide for 1 or 5 hours at 37°C [2] 43°C heat shock for 15 minutes followed by 1 or 5 hours at 37°C This SuperSeries is composed of the following subset Series: GSE866: CP 1hr GSE869: HS 1hr GSE870: HS 5hr GSE888: CP 5hr
ORGANISM(S): Mus musculus 
2004-02-23 | E-GEOD-905 | biostudies-arrayexpress
TranscriptomicsNanostring profiling for immunologically relevant genes on RNA samples isolated from E. coli stimulated human FIP2 silenced macrophages
In order to investigate the importance of FIP2 on bacterially induced gene regulation, we performed a targeted transcriptome profiling for immunologically relevant genes on RNA samples isolated from E. coli stimulated human macrophages from 7 donor treated with non-targeting and FIP2 silencing siRNA...
ORGANISM(S): Homo sapiens 
2019-03-08 | E-MTAB-6790 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of Postnatal Day 10 Wild-type and Nfix KO Subventricular Zone-derived Primary Monolayer-cultured Neural Stem Cells
Purpose: To study the mechanisms involved in the regulation by NFIX on neural stem cell development and to examine the transcriptome changes associated with the loss of NFIX in neural stem cells. Methods: Subventricular zones of 10-day-old wild-type and Nfix KO mice were sectioned and dissociated in...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-65337 | biostudies-arrayexpress
TranscriptomicsComparison of murine colonic mucosal DNA from postnatal day 90 (P90) to postnatal day 30 (P30) by MSAM
DNA methylation profiling of colonic mucosal DNA between P90 and P30 mice. 0.5ug of DNA was serially digested with SmaI and XmaI followed by an adaptor ligation and adaptor mediated PCR amplification Two independent P90 to P30 comparisons were performed as follows. Samples were labelled with Cy3 (P3...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18031 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of migratory vs sedentary brown trout (Salmo trutta) and wild vs hatchery Atlantic salmon (Salmo salar)
A total of 55 individuals were analysed: 15 migratory brown trout (Salmo trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Chevenne river, and 10 Atlantic salmon (S. salar) indivi...
ORGANISM(S): Salmo salar 
2006-03-27 | E-MEXP-123 | biostudies-arrayexpress
ProteomicsSecretome from TXNIP knockout human colorectal cell line (DLD1)
Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognised to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify oxaliplatin-induced Thioredoxin Interacting Protein (TXNIP), a ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD051666 | Pride
Human Txnip Colorectal Secreted 
UnknownPhase III randomized study of rituximab/carmustine, etoposide, cytarabine, and melphalan (BEAM) compared with iodine-131 tositumomab/BEAM with autologous hematopoietic cell transplantation for relapsed diffuse large B-cell lymphoma: results from the BMT CTN 0401 trial.
Not available
S-EPMC3635682 | biostudies-literature
TranscriptomicsThe temporal transcriptomic signature of cartilage formation
To study chondrogenesis, we used a chicken limb bud model: We used RNA sequencing, and examined the differences between gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. We sequenced in triplicate at Day 0,1,2,3,4,6,10,15 and also fr...
ORGANISM(S): Gallus gallus 
2023-03-28 | E-MTAB-12770 | biostudies-arrayexpress
TranscriptomicsTranscriptional events during lung recovery from MRSA infection: a mouse pneumonia model
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA infection. However, the molecular pattern and mechanisms of recovery from MRSA...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-36587 | biostudies-arrayexpress
GenomicsPhase I Clinical Trial Describing the Pharmacogenomics of Aspirin

The study protocol for both cohorts has been previously described (Journal of Thrombosis and Thrombolysis 2012:1-12).

HV1 cohort: Briefly 50 healthy volunteers were exposed to two weeks of 325mg/day aspirin after which whole blood RNA was collected in PAXgene tubes and profiled by microarr...

phs000548.v1.p1 | EGA
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