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TranscriptomicsGene regulation in ki-ras transfected murine fibroblasts
Ki-ras gene mutations are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, expression profiling analyses were performed using stable transfected NIH3T3 cells carrying different ki-ras gene...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8372 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse lines on different genetic background
The evolutionarily conserved Delta-Notch cell-cell signal-transduction pathway regulates the determination of various cell fates, which are important for the morphogenesis and development of numerous organs and tissues in many vertebrates and invertebrates. The Dll1 gene was mutated by homologous r...
ORGANISM(S): Mus musculus 
2009-01-01 | E-GEOD-11867 | biostudies-arrayexpress
TranscriptomicsGene regulation in brain, eye and heart of sighted C3H mice
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the...
ORGANISM(S): Mus musculus 
2010-05-23 | E-GEOD-7855 | biostudies-arrayexpress
TranscriptomicsExpression profiling analysis of thymus and brain from EMP3 mutant mice
Background: Epithelial membrane protein 3 (EMP3) was previously reported to be involved in immunological reactions and in tumor as potential suppressor, as well as a candidate gene for cardiac dystrophic calcification (DCC). Given its assumed role in different disorders, we aimed to generate and per...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-19871 | biostudies-arrayexpress
TranscriptomicsLoss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced bodyweight, partia...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-14454 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of novel ERBB2 (HER2, NEU) targets including genes
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-16445 | biostudies-arrayexpress
TranscriptomicsMultiple functions for Eya3 in mammalian organism
The important function of Eya (eyes absent) in eye development of D.melanogaster is well known, the function of its mammalian orthologs Eya1-4 is only partially understood. Yet, no phenotype for Eya2 and Eya3 in humans or mouse have been described. In our study we analysed new Eya-deficient mouse m...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-9999 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse line
BACKGROUND: The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, invo...
ORGANISM(S): Mus musculus 
2009-03-01 | E-GEOD-12954 | biostudies-arrayexpress
TranscriptomicsAFP1 kO: Expression profiling analysis of embryonic and adult liver
The alpha-fetoprotein (AFP) gene is a member of the albumin gene family and encodes a serum glycoprotein with an onco-fetal pattern of expression. AFP is produced in high concentrations during embryonic life by the hepatocytes and the visceral endoderm of the yolk sac and to a lesser extent by the d...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-20561 | biostudies-arrayexpress
TranscriptomicsExpression profiling analysis of brain from ADAR2 mutant mice
ADARs, short for adenosine deaminases acting on RNA, were first found by their characteristic activity of deaminating up to 50% of all adenosines in double-stranded RNA in vitro. C. elegans has two ADARs, only one is found in the fly, and mammals express three ADARs. Importantly, the spectrum of phy...
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-15383 | biostudies-arrayexpress
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