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ProteomicsOenothera effect on senescent NDHF
Accumulation of senescent dermal fibroblasts drives skin aging, impairing the integrity of the extracellular matrix (ECM) and the function of neighbouring cells. One of strategies to manipulate cell senescence include the reactivation of proliferation. Here, a data independent mass spectrometry base...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034222 | Pride
Hydrophilic extract of oenothera biennis cell cultures  senescence  proteomics  data independent mass spectrometry  fibroblasts 
TranscriptomicsGene expression profiling of miR27a over-expressing RH36 cell lines.
In order to identify direct or indirect miR-27a modulated genes, RH36 cells transfected with miR-27a precursors (pre-miR-27a or pre-control), analyzed 48h post-transfection, were used to perform microarray analysis. Gene expression profiling was carried out in ERMS cell line (RH36) transfected with...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-GEOD-52678 | biostudies-arrayexpress
TranscriptomicsEffects of the expression of M1775R and A1789T BRCA1 missense variants on the transcriptome of HeLa cells
BRCA1 (breast cancer 1, early onset) mutations confer a high breast and ovarian cancer risk. Most of BRCA1 cancer-predisposing mutations originate truncated proteins, but missense mutations have also been detected in familial breast and ovarian cancer patients. These variants are rare and their role...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-MTAB-761 | biostudies-arrayexpress
TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
UnknownNeurodevelopment in schizophrenia: the role of the wnt pathways.
Not available
S-EPMC3763761 | biostudies-literature
TranscriptomicsMicroRNA profile in patients with multiple sclerosis versus healthy controls.
We tested the expression profile of 1146 miRNAs in PBMCs of 19 MS patients and 14 controls (discovery sample) and we explored their function either in vivo by performing a whole-genome mRNA profiling in same patients and in silico using bioinformatic prediction tool (miRbase software). These approac...
ORGANISM(S): Homo_sapiens 
2011-02-27 | E-MTAB-359 | biostudies-arrayexpress
TranscriptomicsmRNA profile in patients with multiple sclerosis versus healthy controls.
We tested the expression profile of 1146 miRNAs in PBMCs of 19 MS patients and 14 controls (discovery sample) and we explored their function either in vivo by performing a whole-genome mRNA profiling in same patients and in silico using bioinformatic prediction tool (miRbase software). These approac...
ORGANISM(S): Homo_sapiens 
2011-02-27 | E-MTAB-358 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis to detect fusion genes in pediatric BCP-ALL
Whole transcriptome RNA-seq of pediatric infant (<1year of aget at diagnosis) patients affected by B-cell precursor Acute Lymphoblastic leukemia (BCP-ALL). The aim of the study is to identify fusion gene rearrangements involved in childhood leukemia, using Next Generation Sequencing (NGS)
ORGANISM(S): Homo sapiens 
2021-10-25 | E-MTAB-9925 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition, simulated by a ground-based Rotating Wall Vessel (RWV) bioreactor. Our results show that 42 miRNAs were differentially expressed in MMG-incubated PBLs...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-57400 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human peripheral blood lymphocytes cultured in modeled microgravity
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition, simulated by a ground-based Rotating Wall Vessel (RWV) bioreactor. Our results show that 42 miRNAs were differentially expressed in MMG-incubated PBLs...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-57408 | biostudies-arrayexpress
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