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TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF): Expression analysis of directed gene deletion mutants.
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41547 | biostudies-arrayexpress
TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF)
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41546 | biostudies-arrayexpress
MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
TranscriptomicsSafety assessment of novel foods using omics profiling combined with one-class classifiers
Food safety evaluation of new, genetically modified (GM) plant varieties has led to basic questions regarding the safety assessment of new plant varieties and whole foods derived thereof. An important part of the hazard identification in the European approach is a targeted compositional analysis of ...
ORGANISM(S): Solanum tuberosum 
2014-03-04 | E-MTAB-1707 | biostudies-arrayexpress
TranscriptomicsBiomarkers for Down Syndrome screening in murine fetal liver and placenta
The Ts1Cje mouse strain (Sago, 1998) contains a segmental trisomy of mouse chromosome 16 orthologous to the region of human chromosome 21 commonly associated with Down Syndrome. In this study, fetuses were obtained from wildtype mothers bred with either wildtype or Ts1Cje males. Gene expression prof...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-24272 | biostudies-arrayexpress
UnknownClinical Characteristics of Patients Undergoing Right Heart Catheterizations in Community Hospitals.
Not available
S-EPMC9496424 | biostudies-literature
ProteomicsPU1 interactome in human monocyte derived dendritic cells
Human monocyte-derived DC were cultured at a density of 0.5x10E6 cells/ml in RPMI-1640 supplemented with 10% FCS, 1% Pen/Strep, 10 ng/ml GM-CSF and 10 ng/ml IL4. At day 7, they were stimulated or not with 500 ng/ml LPS. Cells were collected at day 10. Whole cell lystaes from 2x10E8 cells were used f...
ORGANISM(S): Homo Sapiens 
2018-11-30 | MSV000083175 | MassIVE
TranscriptomicsGPM6B regulates osteoblast differentiation and induction of mineralization by controlling cytoskeleton and matrix vesicle release.
Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26004 | biostudies-arrayexpress
TranscriptomicsLong-term Exposure to Sorafenib of Liver Cancer Cells Induces Resistance with Epithelial-to-Mesenchymal Transition, Increased Invasion and Risk of Rebound Growth
Sorafenib leads to a survival benefit in patients with advanced hepatocellular carcinoma but its use is hampered by the occurrence of drug resistance. To investigate the molecular mechanisms involved we developed five resistant human liver cell lines in which we studied morphology, gene expression a...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-62813 | biostudies-arrayexpress
UnknownNoninvasive Prediction of Elevated Wedge Pressure in Pulmonary Hypertension Patients Without Clear Signs of Left-Sided Heart Disease: External Validation of the OPTICS Risk Score.
Not available
S-EPMC7792270 | biostudies-literature
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