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TranscriptomicsT cell help controls the speed of the cell cycle in germinal center B cells.
The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC and are then selected by T cells in the light zone (LZ) on the basis of affinity. H...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-71295 | biostudies-arrayexpress
ProteomicsHIV-1 Nef changes the proteome of T cells extracellular vesicles
Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in health and disease. Nef is a human immunodeficiency virus (HIV) virulence factor that is released from cells within EVs and is present in plasma EVs of HIV-1 infected individuals. We performed a quantitative pro...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-01-26 | PXD041028 | Pride
Hiv-1 Nef Exosomes Extracelular vesicles 
ProteomicsMicrobial metabolite Indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation
The gut microbiota and its metabolites critically regulate immune cell phenotype, function, and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify modulators of mitochondrial metabolism in T cells. Here, we show that indole-3-propionic acid (IPA) stimulates...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-28 | PXD057537 | Pride
Gut microbiota Indole-3-propionic acid (ipa) Immunometabolism Inflammatory bowel disease (ibd) Cd4+ t cell 
UnknownA new species of Centris ( Centris) (Fabricius) from northeastern Brazil, with taxonomic notes on C. ( C.) pulchra Moure, Oliveira & Viana (Hymenoptera, Apidae).
Not available
S-EPMC3560858 | biostudies-literature
ProteomicsTcI and TcII DTUs isolated from chronic chagasic cardiac patients LC-MSMS
This work aimed to investigate the differential expression of proteins from two distinct genetic groups of T. cruzi (´DTUs´, TcI and TcII), isolated from chronically infected individuals displaying the cardiac form of Chagas’ disease. For this purpose, epimastigote forms of the two isolates were cul...
ORGANISM(S): Trypanosoma cruzi 
2019-11-12 | PXD011172 | Pride
T. cruzi  dtus  differential proteomics  chagas's disease 
TranscriptomicsGene expression analysis of T cell subsets from MS patients undergoing autologous hematopoietic stem cell transplantation reveals significant changes in immune function
Multiple sclerosis is an immune mediated disease of the central nervous system. High-dose immunosuppression therapy followed by autologous hematopoietic stem cell transplantation (HDI/AHSCT) has emerged in the past few years as a new treatment strategy in patients with severe MS and refractory to co...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-32988 | biostudies-arrayexpress
TranscriptomicsOSCC whole genome expression by T stage
Differentially expressed genes between T4 and T1 stage human oral squamous cell carcinoma (OSCC) 36 OSCC samples separated by tumor size T stage, in dual color microarray, using a pool of human cell lines as control. Screening for differentially expressed genes was performed in a cohort of 36 patien...
ORGANISM(S): Homo sapiens 
2015-06-23 | E-GEOD-59069 | biostudies-arrayexpress
TranscriptomicsPotential Roles of miR-29a in the Molecular Pathophysiology of T-Cell Acute Lymphoblastic Leukemia
The miR-29 family is an important player in the molecular pathophysiology of distinct types of cancer, with roles that seems to depend on cellular context. Reduced miR-29 levels are associated with more aggressive disease and its overexpression in cancer and leukemic cell lines inhibits proliferatio...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48063 | biostudies-arrayexpress
ProteomicsProteomic analysis of the membrane-enriched fraction of trypomastigostes released from wild type, LAMP1/2 KO or LAMP2 KO fibroblasts
Trypanosoma cruzi invades non-professional phagocytic cells by subverting their membrane repair process, which is dependent on membrane injury and cell signaling, intracellular calcium increase and lysosome recruitment. Cells lacking Lysosome Associated Membrane Proteins 1 and 2 are less permissive ...
ORGANISM(S): Trypanosoma cruzi 
2022-02-17 | PXD028897 | Pride
Membrane-enriched fraction Tmt labeling Trypanosoma cruzi 
UnknownPersistent Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection in the Placenta of Pregnant Women.
Not available
S-EPMC12412083 | biostudies-literature
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