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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsNovel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy ...
2022-01-18 | MTBLS882 | MetaboLights
TranscriptomicsMF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I independent mechanism of action
Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 6h by in-vivo intramuscularly administration of MF59, alum, CpG, resiquimod (R848), Pam3CSK4 and DMSO and PBS controls. Analysis of splenocyte gene expression signature induced by the same treatments after...
ORGANISM(S): Mus musculus 
2012-02-22 | E-MTAB-942 | biostudies-arrayexpress
ProteomicsComparison of the MHC I immunopeptidome repertoire of B-cell lymphoblasts using two isolation methods
Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility complex class I (MHC I) molecules, and enabled a greater understanding of the dynamic nature of the immunopeptidome of...
ORGANISM(S): Homo sapiens (Human) 
2018-03-09 | PXD007935 | Pride
B-cell Human Ip Mips Mhc i-associated peptides Mae 
Unknownπ-Extended Ru-COUBPY Photosensitizers for <i>In Vivo</i> Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light.
Not available
S-EPMC12715793 | biostudies-literature
GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
UnknownHuman ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice.
Not available
S-EPMC6387412 | biostudies-literature
UnknownUnveiling the Metabolic Changes on Muscle Cell Metabolism Underlying p-Phenylenediamine Toxicity.
Not available
S-EPMC5338303 | biostudies-literature
TranscriptomicsHDL suppresses the type I interferon response
Background: High density lipoprotein (HDL) protects the artery wall by removing cholesterol from lipid-laden macrophages. However, recent evidence suggests that it might also inhibit atherogenesis by combating inflammation. Methods and Results: To identify potential anti-inflammatory mechanisms, we ...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-19340 | biostudies-arrayexpress
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