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UnknownDecoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease.
Not available
S-EPMC7114298 | biostudies-literature
UnknownDeletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Not available
S-EPMC7884788 | biostudies-literature
ProteomicsDeep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
The deubiquitylating enzyme USP18 is a major negative regulator of the interferon (IFN) signalling cascade. IFN pathways contribute to resistance to conventional chemotherapy, radiotherapy, and immunotherapy and are often upregulated in certain tumours, including breast, lung, and colon tumours. USP...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018299 | Pride
Human Cancer Deisgylating enzyme Proteomics Usp18 Isg15 Immunotherapy 
UnknownNidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities.
Not available
S-EPMC4125544 | biostudies-literature
ProteomicsUSP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins
The ubiquitin-like modifier ISG15 can modulate host and viral proteins to restrict viral and microbial infections, and act as a cytokine. Its expression and conjugation are strongly up-regulated by type I interferons. Here we identify the deubiquitinating enzyme USP16 as an ISG15 cross-reactive prot...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD043553 | Pride
Usp16 Innate immunity Metabolic enzyme Isg15 
UnknownSARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.
Not available
S-EPMC4447217 | biostudies-literature
UnknownMechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison.
Not available
S-EPMC12221285 | biostudies-literature
UnknownThe vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference.
Not available
S-EPMC3992837 | biostudies-literature
UnknownMechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41.
Not available
S-EPMC11160589 | biostudies-literature
UnknownStructure of the multiple functional domains from coronavirus nonstructural protein 3.
Not available
S-EPMC7832007 | biostudies-literature
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