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TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in non B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39108 | biostudies-arrayexpress
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
UnknownDevelopment and Implementation of a Safety Incident Report System for Health Care Discipline Students During Clinical Internships: Observational Study.
Not available
S-EPMC11294782 | biostudies-literature
UnknownLow-value care practice in headache: a Spanish mixed methods research study.
Not available
S-EPMC7288523 | biostudies-literature
UnknownParticipatory learning to enhance leadership competence in nursing students: a feasibility study.
Not available
S-EPMC12570632 | biostudies-literature
UnknownComparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection.
Not available
S-EPMC8045426 | biostudies-literature
TranscriptomicsVav proteins orchestrate a keratinocyte auto/paracrine program critical for skin tumorigenesis.
Cutaneous squamous tumors rely on autocrine/paracrine loops for proper fitness. Targeting this Achilles’ heel is therefore considered a potential avenue for patient treatment. However, the mechanisms that engage and sustain such programs during tumor ontogeny are poorly understood. Here, we show ...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-40849 | biostudies-arrayexpress
UnknownA Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia.
Not available
S-EPMC7722692 | biostudies-literature
TranscriptomicsExpression data from human brain samples
Spontaneous intracerebral hemorrhage (ICH) represents about 15% of all strokes and is associated with high mortality rates. Our aim was to identify the gene expression changes and biological pathways altered in the brain following ICH. Twelve brain samples were obtained from four deceased patients w...
ORGANISM(S): Homo sapiens 
2010-09-23 | E-GEOD-24265 | biostudies-arrayexpress
Genomicsena-DATASET-Hospital Clinic Barcelona-12-08-2015-11:33:40:243-146 - samples
Exome Sequencing. 3 μg of genomic DNA from each sample were sheared and used for the construction of a paired-end sequencing library as described in the paired-end sequencing sample preparation protocol provided by Illumina41. Enrichment of exonic sequences was then performed for each library usi...
EGAD00001001464 | EGA
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