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ProteomicsP-VIS: internally-controlled validation of mass spectrometry-based peptide identifications
Peptide-Spectrum Match (PSM) Validation with Internal Standards (P-VIS) is an objective approach to validating individual PSMs. A biological sample is analyzed by LC-MS/MS and the data are searched using a traditional approach such as a database search or de novo sequencing. A PSM of interest is ide...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-21 | PXD020901 | Pride
Peptidomics Hybrid insulin peptides Peptide-spectrum match Post-translational modification Validation Immunotherapy Peptide splicing Immunopeptidomics 
ProteomicsNOD Mouse Islet Peptide Content Identification
Beta-cells produce hybrid insulin peptides (HIPs) by linking insulin fragments to other peptides through peptide bonds. HIPs have unique amino acid sequences and are targeted by autoreactive T cells in type 1 diabetes (T1D). Individuals with recent-onset T1D have significantly higher levels of HIP-r...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD041616 | Pride
Hips Nod mouse Islet cells Peptides Lc-msms 
ProteomicsProteomics of Enriched Insulin Secretory Granules Fractionated by Size Exclusion Chromotography
Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs, which have been confidently identified in pancreatic islets by mass spectrometry, are targeted by CD4 T cells in subjects with Type 1 Diabetes (T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD032664 | Pride
Beta cell Proteins Insulin secretory granule Proteases 
ProteomicsStrategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice
Hybrid insulin peptides (HIPs) form in pancreatic beta cells through the covalent cross-linking of proinsulin peptides with various beta cell peptides, creating unique amino acid sequences not encoded in the genome. HIPs have been confidently identified in both human and mouse islets by mass spectro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-22 | PXD063329 | Pride
Nod Hybrid insulin peptides Insulin Type 1 diabetes 
ProteomicsIdentification of HIPs in the islets of mice and non-diabetic human donors
Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-07 | PXD011606 | Pride
Hybrid insulin peptides (hips) Pancreatic islets 
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
UnknownPredicting 2-year time to progression in diffuse large B cell lymphoma using 3D CNNs on whole-body PET/CT scans.
Not available
S-EPMC12662970 | biostudies-literature
UnknownBlood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.
Not available
S-EPMC8260104 | biostudies-literature
UnknownA global multiproxy database for temperature reconstructions of the Common Era.
Not available
S-EPMC5505119 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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