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UnknownGlobal and Site-Specific Effect of Phosphorylation on Protein Turnover.
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S-EPMC7855865 | biostudies-literature
ProteomicsGlobal and site-specific effect of phosphorylation on protein turnover
The effects of specific modification types and sites on protein lifetime have not been illustrated in large scale. We describe a proteomic method, DeltaSILAC, to quantify the impact of site-specific phosphorylation on the turnover of thousands of proteins in live cells. Being configured on the accur...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2020-11-17 | PXD017496 | Pride
Phosphoproteomics Cell line Dia Turnover Lumos 
ProteomicsHypothesis-free Illustration on How Phosphorylation Dynamically Impact Protein Turnover
The turnover measurement of proteins and proteoforms has been largely facilitated by the metabolic labeling coupled with mass spectrometry (MS), such as the dynamic Stable isotope labeling by amino acids in cell culture (SILAC) experiments, i.e., the dynamic SILAC or pSILAC approach. Very recent stu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-01 | PXD037360 | Pride
Peptidoform Phosphorylation Protein turnover Clustering Deltasilac Dia-ms Pulse silac Data analysis Time course 
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