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In the era of open-modification search engines, more post-translational modifications than ever can be detected by LC-MS/MS-based proteomics. This development can switch proteomics research into a higher gear, as PTMs are key in many cellular pathways important in cell proliferation, migration, meta...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043476 | Pride
Background: With less than a 5% survival rate pancreatic adenocarcinoma (PDAC) is almost uniformly lethal. In order to make a significant impact on survival of patients with this malignancy, it is necessary to diagnose the disease early, when curative surgery is still possible. Detailed knowledge of...
ORGANISM(S): Homo sapiens 
Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but committed precursors for plasmacytoid DCs (pDCs) have not been found. Here we show that CDP-derived ‘CCR9-...
ORGANISM(S): Mus musculus 
Microarray analysis of postnatal NrlGFP-expressing rod photoreceptor precursors. NrlGFP positive versus NrlGFP negative at postnatal day 4
ORGANISM(S): Mus musculus 
For the comparison of 6BG/TMZ with control sample, the predominant annotation among the upregulated genes is M-bM-^@M-^XapoptosisM-bM-^@M-^Y. The majority of the downregulated genes is assigned to heat shock proteins and proteins which bind unfolded proteins. To look at early changes in gene express...
ORGANISM(S): Homo sapiens 
This experiment evaluates whether the gates predicted by the tool ConvexGating improve the isolation of adipocyte precursor subpopulations (P1 and P2) from one high-fat diet (HFD) mouse relative to conventional manual gating. Visceral white adipose tissue (WAT) was chosen as a challenging test case ...
ORGANISM(S): Mus musculus 
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