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UnknownRobust Summarization and Inference in Proteome-wide Label-free Quantification.
Not available
S-EPMC7338080 | biostudies-literature
UnknownMSstats Version 4.0: Statistical Analyses of Quantitative Mass Spectrometry-Based Proteomic Experiments with Chromatography-Based Quantification at Scale.
Not available
S-EPMC10629259 | biostudies-literature
Proteomicsmsqrob2PTM: differential abundance and differential usage analysis of MS-based proteomics data at the post-translational modification and peptidoform level
In the era of open-modification search engines, more post-translational modifications than ever can be detected by LC-MS/MS-based proteomics. This development can switch proteomics research into a higher gear, as PTMs are key in many cellular pathways important in cell proliferation, migration, meta...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043476 | Pride
Msqrob2ptm Ptm Msqrob Peptidoform 
UnknownQuantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjogren's Disease Animal Model.
Not available
S-EPMC12013672 | biostudies-literature
ProteomicsA multiomics approach in refractory DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most frequent entity among non-Hodgkin lymphoma (NHL). It is a clinically and biologically heterogeneous disease regarding treatment response and long-term outcome. The anthracycline-based regimen R-CHOP is still considered as the standard of care for fir...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD009089 | Pride
Human Lymph nodes Lc-ms/ms 
ProteomicsMatrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation
Microenvironmental stiffness regulates fundamental aspects of cell behaviour, including proliferation, differentiation and metabolism, many of which are implicated in cancer initiation and progression. In the mammary gland, extracellular matrix (ECM) stiffness, associated with high mammographic dens...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-04 | PXD063452 | Pride
Ecm Mechanosignalling Mammary epithelia 
ProteomicsWhole Lung Proteome in N. brasiliensis Infection in IL-13 deficient mice.
IL-13 plays a key role during protective type 2 immune responses at mucosal sites, such as during infection with nematodes. However, dysregulation of IL-13 can also contribute to the pathogenesis of allergic and fibrotic diseases. Matrix remodelling is an important component of repair processes in t...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-11 | PXD021853 | Pride
Helminth Mouse Lung Parasite Il-13 
ProteomicsMutation of Arabidopsis SME1 improves oxidative stress resilience
Alternative splicing is an important posttranscriptional gene regulatory process, acting in diverse adaptive and basal plant processes. Splicing of precursor-messenger RNA (pre-mRNA) is catalyzed by a dynamic ribonucleoprotein complex, termed the spliceosome. In a suppressor screen, we identified a ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-03-03 | PXD024816 | Pride
Arabidopsis thaliana Spliceosome Catalase2 Oxidative stress Sm protein 
ProteomicsEffect of the combined loss of tomosyn (STXBP5) and tomosyn-2 (STXBP5L) on the proteome of primary mouse hippocampal neurons
Tomosyn (STXBP5) is a non-canonical SNARE protein enriched in many secretory cells and implicated in regulation of exocytosis. In neurons, loss of tomosyn affects fusion of synaptic vesicles. Here, we examined the impact of the loss of tomosyn (STXBP5) and its close paralog, tomosyn-2 (STXBP5L), on ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-19 | PXD038442 | Pride
Tomosyn Stxbp5 Swath Neuron Synapse Mouse Primaryculture 
ProteomicsProteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Background Semantic dementia (SD) is a subtype of frontotemporal dementia (FTD) characterized by language deficits due to severe temporal lobe degeneration. The consistent neuropathological diagnosis is FTD-TDP subtype C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Desp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033060 | Pride
Semantic dementia Proteomics Mass spectrometry Frontotemporal dementia Tdp-43 
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