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ProteomicsEffect of the combined loss of tomosyn (STXBP5) and tomosyn-2 (STXBP5L) on the proteome of primary mouse hippocampal neurons
Tomosyn (STXBP5) is a non-canonical SNARE protein enriched in many secretory cells and implicated in regulation of exocytosis. In neurons, loss of tomosyn affects fusion of synaptic vesicles. Here, we examined the impact of the loss of tomosyn (STXBP5) and its close paralog, tomosyn-2 (STXBP5L), on ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-19 | PXD038442 | Pride
Tomosyn Stxbp5 Swath Neuron Synapse Mouse Primaryculture 
ProteomicsTomosyn is upregulated by IgE and functions as a PKC-regulated fusion clamp in mast cell degranulation
The regulation of soluble N ethylmaleimide sensitive factor attachment receptor (SNARE) mediated membrane fusion by upstream signaling events is poorly understood. Here we show that the SNARE binding protein tomosyn-1 negatively regulates type I IgE Fc receptor (FcRI) induced degranulation of mast c...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-04 | PXD010047 | Pride
Q-exactive plus Immunoprepicipitations Mast cells Mouse Phosphorylations Ige fc receptor 
UnknownTomosyn interacts with the SUMO E3 ligase PIASγ.
Not available
S-EPMC3948876 | biostudies-literature
UnknownStructural and functional analysis of tomosyn identifies domains important in exocytotic regulation.
Not available
S-EPMC3077652 | biostudies-literature
UnknownTomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Not available
S-EPMC10495110 | biostudies-literature
UnknownTomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.
Not available
S-EPMC5061411 | biostudies-literature
UnknownGenetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis.
Not available
S-EPMC7971124 | biostudies-literature
UnknownTomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Not available
S-EPMC5529015 | biostudies-literature
UnknownTomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.
Not available
S-EPMC356992 | biostudies-literature
UnknownTomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors.
Not available
S-EPMC7216846 | biostudies-literature
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