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ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MutuDC dendritic cell line
Here we used a newly identified Sec61 blocker, mycolactone, to analyze Sec61 contribution to antigen cross presentation, ERAD and transport of internalized antigens into the cytosol in dendritic cells. Shotgun proteomics were used to asses the broad-ranging effects of Sec61 blockade on dendritic cel...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-11 | PXD006103 | Pride
Mouse mutudc dendritic mycolactone sec61 ms/ms lfq 
ProteomicsLC-MS/MS identification of Mycolactone protein targets
Mycolactone is a diffusible macrolide produced by the skin pathogen Mycobacterium ulcerans that suppresses the development of protective immunity against Buruli ulcer disease. In this proteomics study we aimed to identify proteins of which the expression levels changed upon mycolactone treatment. Ju...
ORGANISM(S): Homo sapiens (Human) 
2016-11-04 | PXD002971 | Pride
Mycolactone Silac Jurkat t-cells 
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line
Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 block...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-26 | PXD007770 | Pride
Sec61 Mycolactone Sensory neurons 
MetabolomicsDeciVerneuil (Deciphering the causes of Hidradenitis Suppurativa)
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease, is an incurable skin disease manifesting as recurrent, painful abscesses leading to significant scarring. The estimated worldwide prevalence of HS is around 1%, with highest rates in Europe (1–4%) and a more than 2-fold higher incidenc...
2026-07-27 | MTBLS15166 | MetaboLights
TranscriptomicsTranscription profiling of Mycobacterium bovis with pYUB412 and pRD1-2F9 genes knocked-in to investigate the ESX-1 secretion system
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 kDa culture filtrate protein CFP-10, and is missing from the vaccine strains M.bovis BCG and M.microti. Here, we systematically ...
ORGANISM(S): Mycobacterium bovis 
2007-01-30 | E-BUGS-31 | biostudies-arrayexpress
MetabolomicsEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse mod...

2021-01-21 | MTBLS121 | MetaboLights
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