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ProteomicsProteome and Secretome of Denatonium-treated Mouse Trachea Cells
The peptide-level analysis of proteome and secretome changes of mouse trachea cells upon denatonium treatment (in comparison to Ringer lactate solution control).
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD018170 | Pride
Mouse Lc-ms Denatonium Trachea Secretome 
TranscriptomicsA novel small molecule derived from Lentinula edodes targets PRDX1 to inhibit RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype [Denatonium]
Bone remodeling, crucial for skeletal integrity, involves osteoclasts and osteoblasts. Osteoclastogenesis, regulated by NFATc1, is activated by c-Fos and NF-κB signaling in response to RANKL. Excessive RANKL signaling contributes to bone loss pathology. Here we reveal denatonium as an inhibitor of R...
ORGANISM(S): Mus musculus 
2024-06-30 | GSE248992 | GEO
GenomicsA novel small molecule derived from Lentinula edodes targets PRDX1 to inhibit RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype [Denatonium]
A novel small molecule derived from Lentinula edodes targets PRDX1 to inhibit RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype [Denatonium]
PRJNA1046553 | ENA
GenomicsDenatonium as a bitter taste receptor agonist modifies transcriptomic profile and functions of acute myeloid leukemia cells
Denatonium as a bitter taste receptor agonist modifies transcriptomic profile and functions of acute myeloid leukemia cells
PRJNA629046 | ENA
UnknownDenatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway.
Not available
S-EPMC11660935 | biostudies-literature
GenomicsTHE BITTER TASTE RECEPTOR AGONIST DENATONIUM INHIBITS STEMNESS CHARACTERISTICS IN HEMATOPOIETIC STEM CELLS
THE BITTER TASTE RECEPTOR AGONIST DENATONIUM INHIBITS STEMNESS CHARACTERISTICS IN HEMATOPOIETIC STEM CELLS
PRJNA909241 | ENA
UnknownTaste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca2+, cAMP and ACh.
Not available
S-EPMC9367940 | biostudies-literature
TranscriptomicsDenatonium as a bitter taste receptor agonist modifies transcriptomic profile and functions of acute myeloid leukemia cells
Bitter taste receptors (T2Rs) are typical G-protein coupled receptors expressed in various tissue where they are involved in the regulation of physiological processes, thus suggesting a wider function in sensing microenvironment. We analyzed their expression and role in acute myeloid leukemia (AML)....
ORGANISM(S): Homo sapiens 
2020-09-07 | GSE149548 | GEO
UnknownDenatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells.
Not available
S-EPMC7393209 | biostudies-literature
UnknownBitter Taste Receptor Agonist Denatonium Inhibits Stemness Characteristics in Hematopoietic Stem/Progenitor Cells.
Not available
S-EPMC10787278 | biostudies-literature
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