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ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080724 | MassIVE
ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001176 | Pride
Ovarian cancer cell line  drug-resistance  proteomics  rab 5c  cisplatin 
ProteomicsStructural Alternation in Heat Shock Proteins of Activated Macrophages
The inflammatory response of macrophages is an orderly and complex process under strict reg-ulation accompanied by drastic changes in morphology and functions. It is predicted that pro-teins will undergo structural changes during these finely regulated processes. However, changes in structural prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029672 | Pride
Structural proteomics  raw264.7  lps  lip-ms  hsp60 
ProteomicsDown-regulation of Vimentin Increased Drug Resistance in Ovarian Cancer Cells
Cisplatin and other platinum-based drugs are widely used in the treatment of ovarian cancer, but most patients acquire the drug resistance that greatly compromises the efficacy of drugs. Understanding the mechanism of drug resistance is important for finding new therapeutic approaches. In the presen...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002825 | Pride
Ovarian cancer cell line  drug-resistance  proteomics  vimentin  cisplatin 
ProteomicsProfiling Glutathionylome in CD38-mediated Epithelial-Mesenchymal Transition
We engineered a cell system in which the glutathione synthetase (GS) mutant was expressed that catalyzed the formation of a glutathione analogy from azido-alanine to profile changes of glutathionylome in CD38-overexpressing cells.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032233 | Pride
Cd38 glutathionylome epithelial-mesenchymal transition 
ProteomicsGRX deleted Saccharomyces Cerevisiae LC-MSMS
In this study, we used Saccharomyces cerevisiae to investigate the effects of GRX deletion on yeast chronological life span (CLS). Deletion of Grx1 or Grx2 shortened yeast CLS. Quantitative proteomics revealed that GRX deletion increased cellular ROS levels to activate Ras/PKA signal pathway. Our re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-25 | PXD009699 | Pride
Saccharomyces cerevisiae grx ros lc-msms 
ProteomicsGlutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation
Glutathionylation is an important posttranslational modification that protects proteins from further oxidative damage as well as influencing protein structure and activity. In the present study, we demonstrate that the cysteine-42 residue in protein arginine N-methyltransferase 5 (PRMT5) is glutathi...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD020428 | Pride
Glutathionylation Methyltransferase activity Protein arginine n-methyltransferase 5 (prmt5) Reactive oxygen species (ros) Binding affinity 
ProteomicsA549 CD38 secretomic analysis - Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition
Using A549 CD38 overexpression cells to do secretomic analysis
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009916 | Pride
A549 cd38 Secretomic 
ProteomicsHuman A549 CD38, part 1 - Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition
A SILAC labeled in-solution digestion of A549 CD38 cells.
ORGANISM(S): Homo sapiens (Human) 
2018-07-10 | PXD007122 | Pride
Human Cd38 Lung 
ProteomicsHuman A549 CD38, part 2 - Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition
SILAC-Labeled proteomic analysis of A549 CD38 human lung cancer cell
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD007123 | Pride
Human Cd38 Lung 
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