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ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
UnknownEfficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder.
Not available
S-EPMC11334566 | biostudies-literature
UnknownThe Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.
Not available
S-EPMC6532657 | biostudies-literature
UnknownAIM2 in regulatory T cells restrains autoimmune diseases.
Not available
S-EPMC8080937 | biostudies-literature
ProteomicsProfiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy
Antiretroviral therapy (ART) prevents HIV-1 onward transmission and disease progression, leading to excellent prognosis people living with HIV-1 (PWH). However, significant side effects, complications and impaired immune reconstitution still persist along with ART. We aimed to profile proteome chang...
ORGANISM(S): Homo Sapiens 
2022-03-08 | PXD045070 |
UnknownDouble-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction.
Not available
S-EPMC6124417 | biostudies-literature
UnknownSTING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN-Dependent and -Independent Immune-Regulatory Pathways.
Not available
S-EPMC8406342 | biostudies-literature
ProteomicsProteomics data of DMC-treated senescent cells
Three groups of cells, including the control group, the senescent cells group, and the DMC-treated senescent cells group
ORGANISM(S): Homo Sapiens 
2023-11-23 | PXD047192 |
ProteomicsProteomic analysis identified age-associated prognostic biomarkers in pneumonia-derived pediatric sepsis
Pediatric sepsis is a leading cause of mortality in children across the world. Within pediatric sepsis, how developmental age-specific host immune response impact on the occurrence and development of pediatric sepsis is still unknown, especially between infants and toddlers, which were the major sus...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026656 | Pride
Pediatric sepsis Picu 
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
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