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TranscriptomicsTranscription profiling of Drosophila male third instar larva y+ w roX1- roX2-/y vs y+ w roX1+ roX2-/y reveals roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males
Drosophila males double transcription of their single X chromosome to equalize X-linked gene expression with females, which carry two X chromosomes. Increased transcription requires the Male-Specific Lethal (MSL) complex. One of the primary functions of the MSL complex is thought to be enrichment ...
ORGANISM(S): Drosophila melanogaster 
2008-03-13 | E-GEOD-3990 | biostudies-arrayexpress
TranscriptomicsExpression data from human triploid and diploid fibroblast cell cultures
Dosage compensation restores a balanced network of gene expression between autosomes and sex chromosomes in males (XY) and females (XX). In mammals, this is achieved by doubling the expression of X-linked genes in both sexes, together with X inactivation in females. X up-regulation may be controlled...
ORGANISM(S): Homo sapiens 
2009-11-06 | E-GEOD-18877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary gland of Brca and p53 mutants to identifu Brca1 regulated X-linked genes
We compared the expression levels of X-linked genes in the mammary glands of Brca111/11p53+/- mutant and control (p53+/-) mice at three different stages of the mammary cycle: virgin, pregnant day 16.5, and lactation day 1, using a cDNA microarray. In about 690 X-linked genes that are expresse...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5861 | biostudies-arrayexpress
TranscriptomicsExpression analysis in mouse female PGK12.1 ES cells by RNA-seq
Many animal species employ a chromosome-based mechanism of sex determination, which has led to coordinate evolution of dosage compensation systems. Dosage compensation not only corrects the imbalance in the number of X-chromosomes between the sexes, but is also hypothesized to correct dosage imbalan...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-30690 | biostudies-arrayexpress
TranscriptomicsMulti-modal single-cell sequencing of differentiating mESCs using Smart-seq3 and scATAC-seq
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were grown in serum/LIF conditions were differentiated using Fgf2 and Activin A for 1, 2, 4 and 7 days to induce...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-10714 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of differentiating mESCs using Smart-seq3
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were adapted to 2i/LIF and female cells grown in serum/LIF conditions were differentiated using Fgf2 and Activin...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-9324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila msl21 male larvae reveals MSL2 is required for upregulation of male X chromosome but not for expression of autosomal genes
Drosophila males double transcription of their single X chromosome to equalize X-linked gene expression with females, which carry two X chromosomes. Increased transcription requires the Male-Specific Lethal (MSL) complex. The MSL2 protein is essential component of the MSL complex. MSL2 is the only p...
ORGANISM(S): Drosophila melanogaster 
2009-08-07 | E-GEOD-12054 | biostudies-arrayexpress
TranscriptomicsFemale-specific CTCF binding on the inactive X chromosome in mouse
In mammals, genes located on the X chromosome are present in one copy in XY males and two in XX females. To balance the dosage of X-linked gene expression between the sexes one of the two X chromosomes in females is silenced by X inactivation initiated by up-regulation of the lncRNA (long non-coding...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-66262 | biostudies-arrayexpress
TranscriptomicsNucleophosmin binding on the mouse X chromosomes
In mammals, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single allele in somatic cells. To evaluate structural changes associated with allelic silencing, we have applied a recently developed Hi-C assay that uses DNase I for chromatin fragmentation to mous...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-71903 | biostudies-arrayexpress
TranscriptomicsEscape from X inactivation in mouse tissues (RNA-Seq)
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in...
ORGANISM(S): Mus musculus x Mus spretus 
2015-02-20 | E-GEOD-59777 | biostudies-arrayexpress
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