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ProteomicsDNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1
Polycomb Group (PcG) proteins regulate gene expression by modifying chromatin. A key PcG complex, PRC1, has two activities: a ubiquitin ligase activity for histone H2A, and a chromatin compacting/nucleosome bridging activity that can inhibit transcription and chromatin remodeling. In Drosophila, the...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-05-15 | MSV000085418 | MassIVE
TranscriptomicsTranscription profiling of C. elegans embryonic motor neurons.
Background: Differential gene expression specifies the highly diverse cell types that constitute the nervous system. With its sequenced genome and simple, well-defined neuroanatomy, the nematode C. elegans is a useful model system in which to correlate gene expression with neuron identity. The UNC-4...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-8159 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains
Gene expression patterns were investigated in well-defined genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains. cDNA microarrays were used to search for differentially expressed genes in mouse brain. Four mouse strains, known to differ in susceptibilit...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-370 | biostudies-arrayexpress
UnknownEstimated prevalence of Niemann-Pick type C disease in Quebec.
Not available
S-EPMC8604933 | biostudies-literature
UnknownDerivatives of salarin A, salarin C and tulearin A--Fascaplysinopsis sp. metabolites.
Not available
S-EPMC3853741 | biostudies-literature
TranscriptomicsProtective vaccination induces differential miRNA expression in the liver of Balb/c mice during crisis of Plasmodium chabaudi blood-stage malaria
The aim of the present study was to analyze the effect of protective vaccination on the miRNome of the liver during the crisis phase in vaccination-induced self-healing infections of Plasmodium chabaudi in comparison to lethal infections in non-protected Balb/c mice using Agilent’s microRNA expres...
ORGANISM(S): Mus musculus 
2017-04-01 | E-MTAB-5301 | biostudies-arrayexpress
TranscriptomicsProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
The aim of the present study was to analyze the effect of protective vaccination on the transcriptome of the liver towards the end of the crisis phase in vaccination-induced self-healing infections of Plasmodium chabaudi in comparison to lethal infections in non-protected Balb/c mice using Agilentâ€...
ORGANISM(S): Mus musculus 
2016-10-01 | E-MTAB-4791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain tissue from cerebral malaria-resistant and susceptible strains of mice in a time series following infection with Plasmodium berghei
Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (...
ORGANISM(S): Mus musculus 
2007-05-01 | E-MEXP-1018 | biostudies-arrayexpress
MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
ModelsMammalian Cell Cycle
BACKGROUND: In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic intervention, ERBB2 is targeted by monoclonal antibody trastuzumab in adjuvant settings; however, de novo resistance to t...
1607 | Cell Collective
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