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ProteomicsCytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA
The cytotoxic mechanisms of thymidylate synthase inhibitors, such as the multitarget antifolate pemetrexed, are not yet fully understood. Emerging evidence indicates that combining pemetrexed with histone deacetylase inhibitors (HDACi) may enhance therapeutic efficacy in non-small cell lung cancer (...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD051824 | Pride
Ber Double strand breaks Base excision repair Histone deacetylase Ap Dihydrofolate reductase Dutpase dut Dhfr Apyrimidinic Deoxyuridine triphosphate nucleotide hydrolase Gart Trifunctional purine biosynthetic protein adenosine 3 Hdac Hdaci Dsb 
TranscriptomicsDelta-mbs1 mutant
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30156 | biostudies-arrayexpress
TranscriptomicsToc1, Toc2, and Skn7 null mutants treated with Flucytosine
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30154 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae pGAL1-MKS1, pGAL1-NNK1, and pGAL1-FMP48 overexpression
Analysis of the transcriptional effects of pGAL1-MKS1, pGAL1-NNK1, and pGAL1-FMP48 overexpression. BY4700 gal1::NAT ura3delta0 S. cerevisiae cells carrying a [pGAL1-MKS1-HA, URA3, CEN], [pGAL1-NNK1-HA, URA3, CEN], or [pGAL1-FMP48-HA, URA3, CEN] plasmid, or empty vector BG1805, were grown to early lo...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-25 | E-MEXP-2171 | biostudies-arrayexpress
TranscriptomicsDiverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi
A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent Piwi-interacting RNAs, associate with Argonaute family proteins to regulate gene expression in diverse cellular processes. These two species of small RNA have not been found in fungi. Here, by analyzing small RN...
ORGANISM(S): Neurospora crassa 
2010-07-01 | E-GEOD-21175 | biostudies-arrayexpress
GenomicsHighly integrated single base resolution maps of the epigenome in Arabidopsis
Whole genome shotgun bisulfite sequencing, small RNA sequencing and transcriptome sequencing of wildtype Arabidopsis plants (Col-0), and met1, drm1 drm2 cmt3, and ros1 dml2 dml3 null mutants using the Illumina Genetic Analyzer. A comparison was performed with regions of the genome containing cytosin...
ORGANISM(S): Arabidopsis thaliana 
2008-04-20 | E-GEOD-10877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD
Comparison of lung function in C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD.
ORGANISM(S): Mus musculus 
2007-03-08 | E-MEXP-855 | biostudies-arrayexpress
TranscriptomicsGene expression of Streptococcus mutans pknB mutant versus wild type strain
Bacteria can detect, transmit and react to signals from the outside world by using two-component systems an serine-threonine kinases and phosphatases. Streptococcus mutans contains one serine-threonine kinase, encoded by pknB. A gene encoding a serine-threonine phosphatase, pppL, is located downstre...
ORGANISM(S): Streptococcus mutans UA159 
2010-05-06 | E-GEOD-18355 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae kinase and phosphatase knockouts
All non-essential protein kinases and phosphatases knockouts have been investigated by expression profiling. To investigate redundancy, double mutants are profiled that show a reduced growth according to synthetic genetic interaction data.
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-11 | E-TABM-907 | biostudies-arrayexpress
TranscriptomicsIdentification of mRNAs modulated by knockdown of CD24
We endeavored to identify factors and pathways regulated by CD24 and to obtain leads regarding the mechanism by which CD24 inhibited the invasiveness and metastasis of pancreatic cancer cells by performing cDNA microarray analysis on S2-013 CD24 RNAi clones and control clones. The group of genes sho...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17055 | biostudies-arrayexpress
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