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ProteomicsDEP-1 is a novel brain insulin receptor phosphatase and disallows the development of futile cycles
A healthy metabolism relies on the precise regulation of anabolic and catabolic pathways. Insulin and AMPK serve as key regulators of anabolism and catabolism, respectively. While insulin deficiency markedly impairs anabolism, insulin resistance in obesity leads to metabolic dysfunction especially v...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD051088 | Pride
Brain Insulin Dep-1 
UnknownEnhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.
Not available
S-EPMC4354926 | biostudies-literature
UnknownProtein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
Not available
S-EPMC3064147 | biostudies-literature
ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
UnknownTargeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Not available
S-EPMC3734182 | biostudies-literature
UnknownTumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Not available
S-EPMC2755929 | biostudies-literature
Unknownβ-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans.
Not available
S-EPMC5305270 | biostudies-literature
UnknownThe C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.
Not available
S-EPMC1142556 | biostudies-literature
UnknownContact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.
Not available
S-EPMC2199373 | biostudies-literature
UnknownDEP domain‑containing 1 is a prognostic biomarker associated with the cell cycle in gliomas.
Not available
S-EPMC12005072 | biostudies-literature
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