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GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
ProteomicsSerum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response.
Detailed understanding of host pathogen interaction in tuberculosis is an important avenue for identifying novel therapeutic targets. Small extracellular vesicles (EVs) like exosomes are rich in proteins, nucleic acids and lipids, act as messenger and may show altered composition in disease conditio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-29 | MSV000082412 | MassIVE
UnknownLentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.
Not available
S-EPMC2849517 | biostudies-literature
UnknownViral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis.
Not available
S-EPMC7695858 | biostudies-literature
ProteomicsTime-resolved proteomics of Adenovirus infected cells
To combat virus infections, which are major human killers, a deeper understanding of how viruses reprogram their hosts to create optimal production of progeny is needed. Most knowledge on the regulation of cellular gene expression during adenovirus infection is derived from studies of mRNA expressio...
ORGANISM(S): Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) Homo sapiens (Human) 
2018-10-04 | PXD008980 | Pride
Adenovirus type 2 infection Deregulation of host cell proteins Mass spectrometry Silac. Imr-90 
UnknownThe critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.
Not available
S-EPMC3053133 | biostudies-literature
ProteomicsMS-based proteomics of Adeonvirus type 2 infected primary human cells
To combat virus infections, which are major human killers, a deeper understanding of how viruses reprogram their hosts to create optimal production of progeny is needed. Most knowledge on the regulation of cellular gene expression during adenovirus infection is derived from studies of mRNA expressio...
ORGANISM(S): Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) Homo sapiens (Human) 
2016-12-20 | PXD004095 | Pride
Mass spectrometry Deregulation of host cell proteins Adenovirus type 2 infection Silac Imr-90 
TranscriptomicsTranscription profiling of human lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly due to the technical challenge of analyzing its rare neoplastic L&H cells, which are dispersed in an abundant non-neoplastic cellular microenvironme...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12453 | biostudies-arrayexpress
TranscriptomicsExpression patterns of microRNAs associated with CML phases and their disease related targets
Background MicroRNAs are important regulators of transcription in hematopoiesis. Their expression deregulations were described in association with pathogenesis of some hematological malignancies. This study provides integrated microRNA expression profiling at different phases of chronic myeloid leu...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-26260 | biostudies-arrayexpress
UnknownGenome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection.
Not available
S-EPMC8034727 | biostudies-literature
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