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ProteomicsMachine Learning Identifies Plasma Proteomic Signatures of Descending Thoracic Aortic Disease
Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict their risk of dissection or rupture. This study generated a plasma proteomic dataset from 150 patients with descending thoracic aort...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041337 | Pride
Plasma proteomics Machine learning Type b dissection Descending aortic disease Thoracic aortic aneurysm 
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
UnknownEndovascular treatment outcomes for descending thoracic aortic pathologies in octogenarians: retrospective study.
Not available
S-EPMC12688547 | biostudies-literature
TranscriptomicsTranscription profiling of pig aortic endothelium taken from regions of disturbed and undisturbed flow
This study investigates the role of endothelial cell (EC) gene expression in the focal origin of atherosclerosis, particularly in response to local hemodynamics. Differential gene expression was profiled in EC isolated from athero-susceptible and athero-protected regions of the normal pig aorta. Spe...
ORGANISM(S): Sus scrofa 
2006-07-21 | E-CBIL-17 | biostudies-arrayexpress
UnknownDifferential expansion and outcomes of ascending and descending degenerative thoracic aortic aneurysms.
Not available
S-EPMC9547986 | biostudies-literature
TranscriptomicsGene Array Data from p0 Mouse pup; ascending and descending aortas; fibulin-4 knockout and control
Fibulin-4 plays an essential role in elastic fiber formation, though it's exact function is unclear. Mice lacking the fibulin-4 gene develop cutis laxa with thoracic aortic aneurysms and have narrowed descending aortic diamaters, dying shortly after birth. Another model that disrupt elastic fiber fo...
ORGANISM(S): Mus musculus 
2015-04-10 | E-GEOD-67707 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat model of aging - progressive aortic vasculopathy
This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk fac...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7281 | biostudies-arrayexpress
TranscriptomicsGene expression in tissues of Mus musculus with innate immunity stimulation
This is an investigation of whole genome gene expression level in tissues of mice stimulated by LPS, FK565 or LPS + FK565 in vivo and ex vivo. We show that parenteral administration of a pure synthetic Nod1 ligand, FK565, induces site-specific vascular inflammation in mice, which is prominent in aor...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-20930 | biostudies-arrayexpress
GenomicsEpigenomic code in atherosusceptible endothelia: epigenomic regulation of HOX transcription factors by oxidative stress
Atherosclerosis preferentially develops in arterial regions where hemodynamic disturbed flow and oxidative stress are present. Epigenomic regulation, especially DNA methylation, plays an essential role in regulating gene expression in response to environmental factors. We investigated the DNA methyl...
ORGANISM(S): Sus scrofa 
2015-04-20 | E-MTAB-1930 | biostudies-arrayexpress
TranscriptomicsMurine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7
Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this m...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-51227 | biostudies-arrayexpress
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