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TranscriptomicsTranscriptional Alterations in Skeletal Muscle Following Desmin Deletion
Desmin is a cytoskeletal protein in muscle involved in integrating cellular space and transmitting forces. In this study we sought to determine the effects of desmin deletion on skeletal muscle at the transcriptional level across many pathways of muscle physiology. RNA was isolated from the TA musc...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-34388 | biostudies-arrayexpress
ProteomicsDesmin knock-out cardiomyopathy: a heart on the verge of metabolic crisis
Background: Mutations of the desmin gene cause familial and sporadic cardiomyopathies and myopathies. Previous studies showed that both the lack of desmin and expression of mutated desmin negatively impact on number, structure and function mitochondria implying a metabolic dysfunction as disease pro...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-21 | PXD030938 | Pride
Metabolism Fatty acid Desmin Mitochondria Glucose Desminopathy Desmin knock-out Creatine kinase Cardiomyopathy Amino acid 
GenomicsC2C12 expressing desmin: WT vs Mutations R406W and I451M
C2C12 expressing desmin: WT vs Mutations R406W and I451M
PRJNA769725 | ENA
Proteomicsmuscular changes upon desmin mutation
a knockin mouse model was generatded that expresses the desmin mutant R405W either heterozygotic or homozygotic. the soleus muscle from 6 wt animals and each 6 aniamls with either heterzygotic or homozygotic mutation of desmin were extracted and embedded for cryotome sectioning. Muscle sections from...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD042319 | Pride
Demin Tissue Fiber Muscle 
ProteomicsInvestigation of Interaction Partners of Desmin and Lamin B Proteins Using High Resolution Mass Spectroscopy
The aim of the project is to identify the proteins expected to be participated in desmin-lamin B interaction by high resolution mass spectrometry. Co-immunoprecipitation assay was performed using zebrafish skeletal muscle tissue followed by mass spectrometry to identify interacting proteins. In sili...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-05-10 | PXD047121 | Pride
Lc-ms/ms Skeletal muscle Zebrafish 
GenomicsLack of desmin in mice causes structural and functional disorders of neuromuscular junctions
Lack of desmin in mice causes structural and functional disorders of neuromuscular junctions
PRJNA646716 | ENA
TranscriptomicsC2C12 expressing desmin: WT vs Mutations R406W and I451M
C2C12 cell lines were genetically engineered to stably express WT human Desmin or the Desmin mutant R406W or I451M. Non-modified C2C12 cells were used as control. The goal was to determine the effect of different desmin mutation on the gene expression in a myoblast cell line.
ORGANISM(S): Mus musculus 
2021-10-09 | GSE185589 | GEO
TranscriptomicsTranscriptional Alterations in Skeletal Muscle Following Desmin Deletion
Desmin is a cytoskeletal protein in muscle involved in integrating cellular space and transmitting forces. In this study we sought to determine the effects of desmin deletion on skeletal muscle at the transcriptional level across many pathways of muscle physiology.
ORGANISM(S): Mus musculus 
2012-07-11 | GSE34388 | GEO
UnknownAAV9-mediated gene transfer of desmin ameliorates cardiomyopathy in desmin-deficient mice.
Not available
S-EPMC4976287 | biostudies-literature
TranscriptomicsLack of desmin in mice causes structural and functional disorders of neuromuscular junctions
Desmin, the major intermediate filament (IF) protein in muscle cells, interlinks neighboring myofibrils and connects the whole myofibrillar apparatus to myonuclei, mitochondria, and the sarcolemma. However, desmin is also known to be enriched at postsynaptic membranes of neuromuscular junctions (NMJ...
ORGANISM(S): Mus musculus 
2020-07-17 | GSE154573 | GEO
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