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ProteomicsE. faecium response of ATP-binding protein activity to human serum and colon organoid extract
Enterococcus faecium has emerged as a major nosocomial and opportunistic pathogen, increasingly associated with severe infections such as urinary tract infections, bacteraemia, and endocarditis. Notably, it exhibits intrinsic resistance to many antibiotics and has a remarkable capacity to acquire ad...
ORGANISM(S): Enterococcus faecium 
2026-09-07 | PXD064189 | Pride
Activity-based protein profiling Desthiobiotin-atp Abc transporters Kinases 
ProteomicsDeciphering Staphylococcus aureus-host dynamics using dual Activity-based protein profiling of ATP-interacting proteins
This study focuses on ATP-binding proteins to dissect the complex interplay between Staphylococcus aureus and human cells, particularly macrophages (THP-1) and keratinocytes (HaCaT), during the course of an intracellular infection. A snapshot of the various protein activity and function is provided ...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2024-04-22 | PXD049003 | Pride
Atp-interacting proteins Thp-1 cell infection Staphylococcus aureus Activity-based protein profiling Hacat cel infectionl Host-pathogen interaction 
ProteomicsIntegrated proteome and phosphoproteome analysis of gastric adenocarcinoma reveals molecular signatures capable of stratifying patient outcome
Lymph node metastasis is one of the main causes for the low survival rate of gastric cancer patients. Exploring key proteins players in the progression of gastric adenocarcinoma (GAC) may provide new prognostic parkers and therapeutic strategies. we applied proteomic analysis to compare tumor tissue...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD033622 | Pride
Tnxb  spon1  biomarker  lymph node metastasis  gastric adenocarcinoma 
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
UnknownTargeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases.
Not available
S-EPMC9357193 | biostudies-literature
UnknownActivity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer.
Not available
S-EPMC5217344 | biostudies-literature
ProteomicsMycobacterium tuberculosis ATP-binding Proteome
Mtb was grown as either an actively growing normal culture or as a hypoxia-induced dormant culture. Whole cell lysates of live bacteria were obtained by mechanical disruption with silica beads. ATP-binding proteins were covalently labeled with desthiobiotin-tagged ATP (ActivX, Thermo Pierce). This c...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-04-08 | PXD000141 | Pride
Abpp Atp M. tuberculosis Lc-ms/ms 
UnknownChemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates.
Not available
S-EPMC7370536 | biostudies-literature
UnknownExperimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96.
Not available
S-EPMC4896225 | biostudies-literature
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