Sort   by:  
 Page size 
TranscriptomicsPromotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1(E2F)does not require LIN-35(pRB)
Microarray-based expression profiling of dissected gonads from efl-1, dpl-1 and lin-35 mutants reveals that EFL-1 and DPL-1 promote expression of an extensively overlapping set of target genes, consistent with the expectation that these two proteins function as a heterodimer. Regulatory regions ups...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5071 | biostudies-arrayexpress
TranscriptomicsPositioning of Necrotic Lobular Intraepithelial Neoplasias within the sequence of breast carcinoma progression
Lobular intraepithelial neoplasia grade 3 (LIN) is a recently recognized variant of intraepithelial lobular neoplasia of the breast composed of either uniform, generally small, cells (classic) with massive lobular distension, pleomorphic cells, signet-ring cells, or any cell type with necrosis. In ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14803 | biostudies-arrayexpress
MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
TranscriptomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-30068 | biostudies-arrayexpress
ProteomicsPreferential phosphorylation on old histones during early mitosis in human cells
How histone posttranslational modifications (PTMs) are inherited through cell cycle remains poorly understood. Canonical histones are made in the S phase of cell cycle. Combining mass spectrometry-based technologies and stable isotope labeling by amino acids in cell culture (SILAC), we interrogate t...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003709 | Pride
Mass spectrometry Mitosis Histone modifications Cell cycle Histone phosphorylation 
TranscriptomicsChromosome-biased binding and gene reguation by the C. elegans DRM complex [ChIP-chip]
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we analyze genome-wide binding and function of the C. elegans DRM subunit LIN-54. We demonstrate that LIN-54 DNA-binding activity is required for th...
ORGANISM(S): Caenorhabditis elegans 
2011-04-27 | E-GEOD-28852 | biostudies-arrayexpress
TranscriptomicsTranscript profiling of Lin-Sca-1+c-Kit+ (LSK) cells from mice reconstituted with wild type and necdin null fetal liver cells following a sublethal dose of irradiation (6,5 Gy)
compare the gene expression profile between irradiated Lin-Sca-1+c-Kit+ (LSK) cells from mouse bone marrow reconstituted with wild type and necdin null fetal liver cells The Affymetrix oligonucleotide array was used for this analysis compare the gene expression profile betweenirradiated Lin-Sca-1+c-...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-39153 | biostudies-arrayexpress
TranscriptomicsDRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline
Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...
ORGANISM(S): Caenorhabditis elegans 
2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptome of mice fed high fat diets containing palm or linseed oil
The beneficial effects of dietary long-chain (LC) n-3 polyunsaturated fatty acids (PUFA) in the prevention and/or treatment of some metabolic disorders result largely from their capacity to regulate the transcription level of many genes involved in metabolic and physiological homeostasis, especially...
ORGANISM(S): Mus musculus 
2016-05-18 | E-GEOD-73290 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression of Kit+Sca1+Lin- (KSL) cells from arthritic versus control mice
The involvement of mature hematopoietic cells in disease pathogenesis is well recognized. However it is not clear how if and how primitive progenitors might contribute to inflammatory disease processes. This microarray experiment is used together with data from functional assays to determine how p...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39458 | biostudies-arrayexpress
Sort   by:  
 Page size