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TranscriptomicsInter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response
Glucocorticoids (GCs) are steroid hormones widely used as pharmaceutical interventions, which act mainly by regulating gene expression levels. A large fraction of patients (~30%), especially those of African descent, show a weak response to treatment. To interrogate the contribution of variable tra...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-33649 | biostudies-arrayexpress
TranscriptomicsGenetic mapping with multiple levels of phenotypic information reveals new determinants of lymphocyte glucocorticoid sensitivity
Clinical response to glucocorticoids (GCs), steroid hormones widely used as pharmaceuticals, varies extensively, with many patients (~30%) showing a weak response to treatment. Although little is known about the molecular basis of this variation, regulatory polymorphisms are likely to play a key rol...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48801 | biostudies-arrayexpress
TranscriptomicsComparison of cellular and transcriptional responses to 1,25-dihydroxyvitamin D3 and glucocorticoids in peripheral blood mononuclear cells
Glucocorticoids (GC) and 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) are steroid hormones with anti-inflammatory properties with enhanced effects when combined. We previously showed that transcriptional response to GCs was correlated with inter-individual and inter-ethnic cellular response. Here, we pro...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-50012 | biostudies-arrayexpress
TranscriptomicsPatterns of transcriptional response to 1,25-dihydroxyvitamin D3 and bacterial lipopolysaccharide in primary human monocytes
This study examines patterns of genome-wide transcriptional response to the active form of vitamin D, 1,25-dihyroxyvitamin D3 (1,25D), and the bacterial lipopolysaccharide (LPS) in primary human monocytes, to better understand pathways underlying the immunomodulatory role of 1,25D. Total RNA extrace...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-78083 | biostudies-arrayexpress
TranscriptomicsGenetic, functional and molecular features of glucocorticoid receptor binding (expression)
Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel disease, and certain types of cancer. GCs act mainly by activating the GC receptor (GR), which interacts with other transcription f...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-44248 | biostudies-arrayexpress
GenomicsGenetic, functional and molecular features of glucocorticoid receptor binding (sequencing)
Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and inflammatory bowel disease, and certain types of cancer. GCs act mainly by activating the GC receptor (GR), which interacts with other transcription f...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-45638 | biostudies-arrayexpress
TranscriptomicsInteractions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes
Glucocorticoids (GCs) are steroid hormones produced by the human body in response to environmental stressors. Despite their key role as physiological regulators and widely administered pharmaceuticals, little is known about the genetic basis of inter-individual and inter-ethnic variation in GC respo...
ORGANISM(S): Homo sapiens 
2011-08-17 | E-GEOD-29342 | biostudies-arrayexpress
UnknownESC working group on e-cardiology position paper: use of commercially available wearable technology for heart rate and activity tracking in primary and secondary cardiovascular prevention-in collaboration with the European Heart Rhythm Association, European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professionals, Patient Forum, and the Digital Health Committee.
Not available
S-EPMC9753086 | biostudies-literature
TranscriptomicsMapping Variation in Cellular and Transcriptional Response to 1,25-dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells
This study characterizes the genetic basis of variation in the immunomodulatory effects of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D). This was done by mapping quantitative traits of 1,25D response both at the cellular and transcriptional level in peripheral blood mononuclear ce...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-82023 | biostudies-arrayexpress
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