Sort   by:  
 Page size 
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
MetabolomicsA Randomized Controlled Trial of Shengji Ointment Combined with Bromelain in Promoting Healing of Tendon-Exposed Diabetic Foot Wounds: Metabolomics Profiling Analysis

Background: Diabetic foot tendon exposures are prone to infection, necrosis, and prolonged treatment cycles, not only hindering wound healing but potentially leading to amputation and life-threatening complications. Shengji ointment combined with bromelain has demonstrated preliminary efficacy i...

2025-07-14 | MTBLS12713 | MetaboLights
ProteomicsCurcuminoid Supplementation in Canine Diabetic Mellitus and its Complications using Proteomic Analysis
Diabetes mellitus (DM) is a disorder that disrupts the body from shifting glucose into the cells resulting in hyperglycaemia (1). Insulin dependence or DM that resembles type I diabetes in humans is commonly observed in dogs (2). Canine DM diagnosis is based on fasting hyperglycaemia and glucosuria ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-12-15 | PXD037667 | Pride
Inflammation Curcuminoids Oxidative stress Proteomic Diabetes mellitus 
TranscriptomicsThe role of insulin resistance in experimental diabetic retinopathy - genetic and molecular aspects
Patients with long-duration diabetes develop cardiovascular complications resulting in highly increased mortality and complications which affect the kidneys, eyes and peripheral nerves associated with high morbidity. Among the diabetic complications, damage in the eye, diabetic retinopathy, is the m...
ORGANISM(S): Rattus norvegicus 
2017-03-31 | E-MTAB-5563 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreata, submandibular, and lacrimal glands from NOD-scid and C57Bl/6-scid mice to study the gene expression patterns of nonobese diabetic mice.
Prior to the onset of autoimmune destruction, type 1 diabetic patients and an animal model thereof, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormaliti...
ORGANISM(S): Mus musculus 
2007-11-29 | E-GEOD-4953 | biostudies-arrayexpress
TranscriptomicsExpression of TNFR1, VEGFA, CD147 and MCT1 as early biomarkers of diabetes complications and the impact of aging on this profile
The study of new biomarkers for early detection of diabetes complications could bring new prevent approaches perspectives.
ORGANISM(S): Rattus norvegicus 
2023-05-11 | E-MTAB-13000 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Aqueous Humor Identified Clinically Relevant Molecular Targets for Neovascular Complications in Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of blindness in adults under 40 in the developed world, with a significant proportion progressing to vision-threatening stages like proliferative diabetic retinopathy (PDR) and neovascular glaucoma (NVG). This study aims to explore the molecular mechanism...
ORGANISM(S): Homo sapiens (Human) 
2025-05-01 | PXD058481 | Pride
Diabetic retinopathy Aqueous humor Proteomics 
TranscriptomicsGene Expression of ApoE Null and ApoE Null/RAGE Diabetic and Non-diabetic Mice
The multi-ligand Receptor for AGE (RAGE) contributes to atherosclerosis in apolipoprotein (ApoE) null mice in both the non-diabetic and diabetic states. Previous studies using soluble RAGE, the extracellular ligand-binding domain of RAGE, or homozygous RAGE null mice showed that blockade or deletion...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-15729 | biostudies-arrayexpress
TranscriptomicsCross-species transcriptional networks in Diabetic Glomerulopathy in mouse and man
Murine models have been valuable instruments in defining the pathogenesis of diabetic nephropathy (DN), but they only partially recapitulate disease manifestations of human DN, limiting their utility . In order to define the molecular similarities and differences between human and murine DN, we perf...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-33744 | biostudies-arrayexpress
ProteomicsHuman Lower extremity arteries LC-MS
To explore potential therapeutic targets for diabetic vascular complications, we first conducted an unbiased screen at the protein level with lower extremity vessels from non-diabetic control individuals and from patients with type 2 diabetes by LC-MS/MS (liquid chromatography-tandem mass spectrome...
ORGANISM(S): Homo sapiens (Human) 
2025-09-05 | PXD067778 | Pride
Diabetes human vascular 
Sort   by:  
 Page size